{"id":225081,"date":"2024-11-08T14:33:00","date_gmt":"2024-11-08T14:33:00","guid":{"rendered":"https:\/\/www.merieuxnutrisciences.com\/?p=225081"},"modified":"2025-11-08T17:32:17","modified_gmt":"2025-11-08T17:32:17","slug":"analise-de-extrataveis-em-filtros-para-producao-farmaceutica-estudo-de-caso-sobre-extraiveis-e-lixiviaveis","status":"publish","type":"post","link":"https:\/\/www.merieuxnutrisciences.com\/pt\/analise-de-extrataveis-em-filtros-para-producao-farmaceutica-estudo-de-caso-sobre-extraiveis-e-lixiviaveis\/","title":{"rendered":"An\u00e1lise de Extrat\u00e1veis em Filtros para Produ\u00e7\u00e3o Farmac\u00eautica: Estudo de caso sobre extra\u00edveis e lixivi\u00e1veis"},"content":{"rendered":"<style>.wp-block-kadence-advancedheading.kt-adv-heading225081_b2e241-5c, .wp-block-kadence-advancedheading.kt-adv-heading225081_b2e241-5c[data-kb-block=\"kb-adv-heading225081_b2e241-5c\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225081_b2e241-5c mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225081_b2e241-5c[data-kb-block=\"kb-adv-heading225081_b2e241-5c\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225081_b2e241-5c img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225081_b2e241-5c[data-kb-block=\"kb-adv-heading225081_b2e241-5c\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225081_b2e241-5c wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225081_b2e241-5c\"><strong>Mais uma vez, a nossa experi\u00eancia vai para al\u00e9m da embalagem.&nbsp;<\/strong><\/h2>\n\n\n\n<p>Os extra\u00edveis podem ter origem n\u00e3o s\u00f3 no sistema de embalagem do produto farmac\u00eautico, mas tamb\u00e9m nos <strong>componentes utilizados durante o processo de produ\u00e7\u00e3o que entram em contacto com o medicamento antes da embalagem final.<\/strong><\/p>\n\n\n\n<p>Os processos de fabrico utilizam componentes e pe\u00e7as que podem ser total ou parcialmente constru\u00eddos com materiais pl\u00e1sticos. Ao entrarem em contacto com o fluxo do processo, estes componentes podem interagir com o produto farmac\u00eautico, levando \u00e0 acumula\u00e7\u00e3o de PERL (lixivi\u00e1veis relacionados com o equipamento de processo), e podem alterar a <strong>efic\u00e1cia ou efici\u00eancia das opera\u00e7\u00f5es de processamento subsequentes<\/strong>.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225081_e8a7fa-f4, .wp-block-kadence-advancedheading.kt-adv-heading225081_e8a7fa-f4[data-kb-block=\"kb-adv-heading225081_e8a7fa-f4\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225081_e8a7fa-f4 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225081_e8a7fa-f4[data-kb-block=\"kb-adv-heading225081_e8a7fa-f4\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225081_e8a7fa-f4 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225081_e8a7fa-f4[data-kb-block=\"kb-adv-heading225081_e8a7fa-f4\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225081_e8a7fa-f4 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225081_e8a7fa-f4\"><strong>Como garantir a seguran\u00e7a do sistema?<\/strong><\/h2>\n\n\n\n<p>A amostra \u00e9 um filtro &#8211; utilizado na produ\u00e7\u00e3o de produtos farmac\u00eauticos para inala\u00e7\u00e3o &#8211; caracterizado por uma membrana hidr\u00f3fila. Todos os componentes est\u00e3o listados abaixo:<\/p>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_9bd1e8-c2:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_9bd1e8-c2 ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_9bd1e8-c2 ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_9bd1e8-c2 ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items225081_9bd1e8-c2 ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items225081_9bd1e8-c2 kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-225081_0ba110-2e .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_0ba110-2e\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Composi\u00e7\u00e3o do filtro: polipropileno r\u00edgido.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225081_67975b-88 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_67975b-88\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Composi\u00e7\u00e3o da membrana filtrante: fluoreto de polivinilideno modificado (PVDF).<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225081_9b33cb-91 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_9b33cb-91\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Composi\u00e7\u00e3o da rede: polipropileno <em>spun-bonded<\/em>.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225081_7b952a-5d .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_7b952a-5d\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Composi\u00e7\u00e3o do O-ring: silicone.<\/span><\/li>\n<\/ul><\/div>\n\n\n\n<p><strong>O processo de filtra\u00e7\u00e3o representa uma etapa cr\u00edtica para a ind\u00fastria farmac\u00eautica<\/strong>. Uma filtragem correta garante a seguran\u00e7a do medicamento para os pacientes e a elevada qualidade do produto acabado, evitando a perda de material importante. Al\u00e9m disso, os sistemas de filtragem e os filtros utilizados devem ser eficazes na filtragem de fluidos agressivos em v\u00e1rios pontos do processo.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225081_1086cd-a5, .wp-block-kadence-advancedheading.kt-adv-heading225081_1086cd-a5[data-kb-block=\"kb-adv-heading225081_1086cd-a5\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225081_1086cd-a5 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225081_1086cd-a5[data-kb-block=\"kb-adv-heading225081_1086cd-a5\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225081_1086cd-a5 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225081_1086cd-a5[data-kb-block=\"kb-adv-heading225081_1086cd-a5\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225081_1086cd-a5 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225081_1086cd-a5\"><strong>Objetivo do estudo<\/strong><\/h2>\n\n\n\n<p>O estudo pode ser considerado uma abordagem de &#8220;pior caso&#8221; devido \u00e0s condi\u00e7\u00f5es de contacto e \u00e0 natureza dos meios de extra\u00e7\u00e3o. O objetivo do estudo \u00e9 a caracteriza\u00e7\u00e3o dos compostos extra\u00edveis que possam ser libertados dos tubos de silicone para a produ\u00e7\u00e3o farmac\u00eautica. <strong>Os extra\u00edveis ser\u00e3o caracterizados se estiverem presentes numa concentra\u00e7\u00e3o superior ao Limiar de Avalia\u00e7\u00e3o Anal\u00edtica (AET),<\/strong> calculado com base numa avalia\u00e7\u00e3o Limiar de Preocupa\u00e7\u00e3o de Seguran\u00e7a (SCT) apropriada. O estudo tamb\u00e9m pode representar uma verifica\u00e7\u00e3o da presen\u00e7a de subst\u00e2ncias adicionadas involuntariamente como poss\u00edveis contaminantes ou impurezas do processo.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225081_d87363-a9, .wp-block-kadence-advancedheading.kt-adv-heading225081_d87363-a9[data-kb-block=\"kb-adv-heading225081_d87363-a9\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225081_d87363-a9 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225081_d87363-a9[data-kb-block=\"kb-adv-heading225081_d87363-a9\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225081_d87363-a9 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225081_d87363-a9[data-kb-block=\"kb-adv-heading225081_d87363-a9\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225081_d87363-a9 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225081_d87363-a9\"><strong>A estrat\u00e9gia da M\u00e9rieux NutriSciences para estudos de<\/strong> <strong>extra\u00edveis e lixivi\u00e1veis<\/strong><\/h2>\n\n\n\n<p>A <strong>seguran\u00e7a <\/strong>do produto farmac\u00eautico deve ser <strong>garantida em toda a cadeia de produ\u00e7\u00e3o<\/strong>, considerando tamb\u00e9m os componentes do sistema como parte integrante da abordagem do estudo:<\/p>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_0c8802-60:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_0c8802-60 ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_0c8802-60 ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_0c8802-60 ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items225081_0c8802-60 ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items225081_0c8802-60 kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-225081_f289fa-90 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_f289fa-90\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Estudos de Extra\u00edveis &amp; Lixivi\u00e1veis.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225081_b77e63-4c .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_b77e63-4c\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Avalia\u00e7\u00e3o toxicol\u00f3gica<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225081_a447fc-0d .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_a447fc-0d\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Identifica\u00e7\u00e3o de potenciais riscos para o medicamento<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.kb-image225081_45c562-25 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<div class=\"wp-block-kadence-image kb-image225081_45c562-25\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"676\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2022\/04\/schema_el_website_resized-2.jpg\" alt=\"An\u00e1lise de Extrat\u00e1veis em Filtros para Produ\u00e7\u00e3o Farmac\u00eautica\" class=\"kb-img wp-image-16329\"\/><\/figure><\/div>\n\n\n\n<p>A an\u00e1lise das subst\u00e2ncias extra\u00eddas considerou tanto as mol\u00e9culas org\u00e2nicas como as inorg\u00e2nicas. As <strong>t\u00e9cnicas de despiste cromatogr\u00e1fico utilizadas s\u00e3o combinadas com m\u00e9todos de dete\u00e7\u00e3o altamente sens\u00edveis e de ponta<\/strong>, aplicadas da seguinte forma:<\/p>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_1edf78-2d:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_1edf78-2d ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_1edf78-2d ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225081_1edf78-2d ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items225081_1edf78-2d ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items225081_1edf78-2d kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-225081_221503-4b .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_221503-4b\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>HS-GC\/MS<\/strong> \u2013 Cromatografia em fase gasosa de headspace acoplada a um detetor de espetrometria de massa.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225081_19584f-85 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_19584f-85\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>GC\/MS<\/strong> \u2013 Cromatografia em fase gasosa acoplada a um detetor de massa.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225081_97234f-2f .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_97234f-2f\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>HPLC\/HR-MS Q-Orbitrap<\/strong> \u2013 Cromatografia l\u00edquida de ultra desempenho acoplada a um detetor de massa de alta resolu\u00e7\u00e3o.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225081_585ed5-23 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_585ed5-23\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>ICP\/MS<\/strong> \u2013 Plasma acoplado indutivamente acoplado a um detetor de massa.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225081_3febf5-68 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225081_3febf5-68\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>IC<\/strong> \u2013 Cromat\u00f3grafo i\u00f3nico com detetor de condutividade.<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225081_9f6750-ed, .wp-block-kadence-advancedheading.kt-adv-heading225081_9f6750-ed[data-kb-block=\"kb-adv-heading225081_9f6750-ed\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225081_9f6750-ed mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225081_9f6750-ed[data-kb-block=\"kb-adv-heading225081_9f6750-ed\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225081_9f6750-ed img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225081_9f6750-ed[data-kb-block=\"kb-adv-heading225081_9f6750-ed\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225081_9f6750-ed wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225081_9f6750-ed\"><strong>Resultados<\/strong><\/h2>\n\n\n\n<p>Os resultados obtidos <strong>n\u00e3o revelaram qualquer composto org\u00e2nico acima do limiar de avalia\u00e7\u00e3o anal\u00edtica (AET).<\/strong> Al\u00e9m disso, nenhuma impureza elementar e nenhum ani\u00e3o foram detetados em concentra\u00e7\u00f5es superiores ao limite de quantifica\u00e7\u00e3o do m\u00e9todo instrumental.<\/p>\n\n\n\n<p>Considerando que a estrat\u00e9gia anal\u00edtica foi desenvolvida com base num limiar AET, que serve especificamente para distinguir quais os compostos que necessitam de avalia\u00e7\u00e3o de risco toxicol\u00f3gico, e que nenhum composto foi detetado acima desse limiar, <strong>neste caso n\u00e3o se revelou necess\u00e1rio prosseguir com uma avalia\u00e7\u00e3o toxicol\u00f3gica.<\/strong><\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-225081_5b5f1f-04 .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-225081_5b5f1f-04 .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-225081_5b5f1f-04\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns225081_89a980-cf{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns225081_89a980-cf .kt-button{font-weight:normal;font-style:normal;}.kt-btns225081_89a980-cf .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns225081_89a980-cf .kt-btn-wrap-0 .kt-button{color:#555555;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns225081_89a980-cf .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns225081_89a980-cf .kt-btn-wrap-0 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10px;\n}\n.card-content{\n    display:flex;\n    justify-content: center;\n}\n\n.card-content span{\n    color:var(--global-palette3);\n    text-align: center;\n    text-transform: uppercase;\n    margin: 5px 0;\n    line-height: 1.2em;\n    font-size: 16px;\n    font-weight:bold;\n}\n\n.card:hover {\n    animation: all ease-in-out 0.3s;\n    transform: scale(.95) translate(0px, -100px);\n    box-shadow: 0 4px 8px rgba(0,0,0,0.2);\n}\n\n@media (max-width: 767px) {\n    .page-cards-container {\n        flex-direction: column;\n        align-items: center;\n    }\n    .page-cards-title-container{\n        text-align: center;\n    }\n    \n}\n\n@media (min-width: 768px) and (max-width: 1023px) {\n    .page-cards-container {\n        flex-wrap: wrap;\n        justify-content: space-around;\n    }\n    .page-cards-title-container{\n        text-align: center;\n    }\n\n}\n\n<\/style>\n\n\n\n<style>\n\n    \n.related-card-image {\n    width: 100%;\n    height: 160px;\n    overflow: hidden;\n 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wrap in small screens *\/\n   \n}\n\n.related-articles-block li {\n    background-color: #fff; \/* White background for list items *\/\n    padding: 15px;\n    margin: 10px;\n    width: calc(33.333% - 20px); \/* Three items per row minus margin *\/\n    box-shadow: 0 1px 3px rgba(0,0,0,0.1);\n    border-radius: 4px;\n    text-align: center; \/* Center-align text *\/\n    transition: transform 0.3s ease, box-shadow 0.3s ease; \/* Smooth transitions for hover effects *\/\n}\n\n.related-articles-block li a {\n    text-decoration: none;\n    color: #0073aa; \/* WordPress blue for links *\/\n    font-weight: bold;\n}\n\n.related-articles-block li:hover {\n    transform: translateY(-5px); \/* Slight lift effect on hover *\/\n    box-shadow: 0 4px 6px rgba(0,0,0,0.15);\n}\n.related-card {\n    display: block;\n    width: 100%; \/* Full width within grid item *\/\n    height: 300px;\n    background-color: #ffffff; \/* White background *\/\n    border: 1px solid #e0e0e0; \/* Light grey border *\/\n    border-radius: 8px; \/* Rounded corners *\/\n    text-decoration: none; \/* Removes underline from links *\/\n    color: #333333; \/* Dark grey text *\/\n    transition: all 0.3s ease; \/* Smooth transition for hover effects *\/\n    overflow: hidden; \/* Ensures no content spills outside the border *\/\n}\n\n.related-card-content {\n    padding: 16px; \/* Padding inside the card *\/\n    display: flex; \/* Flexbox to align content *\/\n    align-items: center; \/* Center items vertically *\/\n    justify-content: center; \/* Center content horizontally *\/\n    text-align: center; \/* Center text *\/\n}\n\n.related-card-content span {\n    font-size: 16px; \/* Font size for the title *\/\n    font-weight: bold; \/* Makes font bold *\/\n    color:var(--global-palette3);\n}\n\n.related-card:hover {\n    border-color: var(--global-palette4); \/* Changes border color on hover *\/\n    box-shadow: 0 4px 8px rgba(0, 0, 0, 0.1); \/* Subtle shadow for depth *\/\n    transform: translateY(-5px); \/* Slightly raise the card *\/\n}\n\n\/* Responsive adjustments for smaller screens *\/\n@media (max-width: 768px) {\n    .related-articles-block ul {\n        grid-template-columns: repeat(2, 1fr); \/* Two items per row on smaller screens *\/\n    }\n    .related-card-content {\n        padding: 12px; \/* Smaller padding on smaller screens *\/\n    }\n}\n@media (max-width: 480px) {\n    .related-articles-block ul {\n        grid-template-columns: 1fr; \/* One item per row on very small screens *\/\n    }\n    .related-articles-block h2,\n    .related-articles-block .related-articles-subtitle {\n        text-align: center;\n    }\n}\n<\/style>","protected":false},"excerpt":{"rendered":"<p>Mais uma vez, a nossa experi\u00eancia vai para al\u00e9m da embalagem.&nbsp; Os extra\u00edveis podem ter origem n\u00e3o s\u00f3 no sistema de embalagem do produto farmac\u00eautico, mas tamb\u00e9m nos componentes utilizados durante o processo de produ\u00e7\u00e3o que entram em contacto com o medicamento antes da embalagem final. Os processos de fabrico utilizam componentes e pe\u00e7as que&#8230;<\/p>\n","protected":false},"author":16,"featured_media":20236,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[1754],"tags":[],"post_folder":[],"class_list":["post-225081","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-produtos-farmaceuticos"],"acf":[],"taxonomy_info":{"category":[{"value":1754,"label":"Produtos farmac\u00eauticos"}]},"featured_image_src_large":["https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2022\/05\/mxns_CardEL_4_Website_ENG_newsito.jpg",1024,299,false],"author_info":{"display_name":"Rui Nogueira","author_link":"https:\/\/www.merieuxnutrisciences.com\/pt\/author\/rui\/"},"comment_info":0,"category_info":[{"term_id":1754,"name":"Produtos farmac\u00eauticos","slug":"produtos-farmaceuticos","term_group":0,"term_taxonomy_id":1754,"taxonomy":"category","description":"","parent":0,"count":3,"filter":"raw","cat_ID":1754,"category_count":3,"category_description":"","cat_name":"Produtos farmac\u00eauticos","category_nicename":"produtos-farmaceuticos","category_parent":0}],"tag_info":false,"_links":{"self":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts\/225081","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/comments?post=225081"}],"version-history":[{"count":3,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts\/225081\/revisions"}],"predecessor-version":[{"id":225097,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts\/225081\/revisions\/225097"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/media\/20236"}],"wp:attachment":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/media?parent=225081"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/categories?post=225081"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/tags?post=225081"},{"taxonomy":"post_folder","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/post_folder?post=225081"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}