{"id":225072,"date":"2024-11-08T14:12:53","date_gmt":"2024-11-08T14:12:53","guid":{"rendered":"https:\/\/www.merieuxnutrisciences.com\/?p=225072"},"modified":"2025-11-08T17:34:59","modified_gmt":"2025-11-08T17:34:59","slug":"estudo-sobre-extraiveis-em-tubos-de-silicone-utilizados-na-producao-de-produtos-farmaceuticos-estudo-de-caso-sobre-extraiveis-e-lixiviaveis","status":"publish","type":"post","link":"https:\/\/www.merieuxnutrisciences.com\/pt\/estudo-sobre-extraiveis-em-tubos-de-silicone-utilizados-na-producao-de-produtos-farmaceuticos-estudo-de-caso-sobre-extraiveis-e-lixiviaveis\/","title":{"rendered":"Estudo sobre extra\u00edveis em tubos de silicone utilizados na produ\u00e7\u00e3o de produtos farmac\u00eauticos: Estudo de caso sobre extra\u00edveis e lixivi\u00e1veis"},"content":{"rendered":"<style>.wp-block-kadence-advancedheading.kt-adv-heading225072_551f2c-3e, .wp-block-kadence-advancedheading.kt-adv-heading225072_551f2c-3e[data-kb-block=\"kb-adv-heading225072_551f2c-3e\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225072_551f2c-3e mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225072_551f2c-3e[data-kb-block=\"kb-adv-heading225072_551f2c-3e\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225072_551f2c-3e img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225072_551f2c-3e[data-kb-block=\"kb-adv-heading225072_551f2c-3e\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225072_551f2c-3e wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225072_551f2c-3e\"><strong>A nossa experi\u00eancia vai para al\u00e9m da embalagem.&nbsp;<\/strong><\/h2>\n\n\n\n<p>Os extra\u00edveis podem ter origem n\u00e3o s\u00f3 no sistema de embalagem do produto farmac\u00eautico, mas tamb\u00e9m nos <strong>sistemas e componentes utilizados durante o processo de produ\u00e7\u00e3o<\/strong> que entram em contacto com o medicamento antes da embalagem final.<\/p>\n\n\n\n<p>Os processos de produ\u00e7\u00e3o utilizam componentes e sistemas que podem ser total ou parcialmente constitu\u00eddos por materiais pl\u00e1sticos. Em contacto com o fluxo do processo, estes componentes interagem diretamente com o medicamento antes do seu embalamento final, levando \u00e0 acumula\u00e7\u00e3o de PERL (lixivi\u00e1veis relacionados com o equipamento de processo), que podem alterar a efic\u00e1cia ou a efici\u00eancia das subsequentes opera\u00e7\u00f5es de produ\u00e7\u00e3o.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225072_0870ef-23, .wp-block-kadence-advancedheading.kt-adv-heading225072_0870ef-23[data-kb-block=\"kb-adv-heading225072_0870ef-23\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225072_0870ef-23 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225072_0870ef-23[data-kb-block=\"kb-adv-heading225072_0870ef-23\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225072_0870ef-23 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225072_0870ef-23[data-kb-block=\"kb-adv-heading225072_0870ef-23\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225072_0870ef-23 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225072_0870ef-23\"><strong>Como garantir a seguran\u00e7a do sistema?<\/strong><\/h2>\n\n\n\n<p>Neste caso, a amostra era um tubo de silicone para uso repetido. Os tubos s\u00e3o utilizados durante a produ\u00e7\u00e3o farmac\u00eautica por um n\u00famero espec\u00edfico de semanas por ano, durante alguns anos, exceto se houver danos. Os tubos s\u00e3o lavados com \u00e1gua e esterilizados em autoclave ap\u00f3s cada utiliza\u00e7\u00e3o. O tempo de contacto entre os tubos e o produto farmac\u00eautico tamb\u00e9m \u00e9 fixo.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225072_0b4258-d5, .wp-block-kadence-advancedheading.kt-adv-heading225072_0b4258-d5[data-kb-block=\"kb-adv-heading225072_0b4258-d5\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225072_0b4258-d5 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225072_0b4258-d5[data-kb-block=\"kb-adv-heading225072_0b4258-d5\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225072_0b4258-d5 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225072_0b4258-d5[data-kb-block=\"kb-adv-heading225072_0b4258-d5\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225072_0b4258-d5 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225072_0b4258-d5\"><strong>Objetivo do estudo<\/strong><\/h2>\n\n\n\n<p>O estudo pode ser considerado uma abordagem de &#8220;pior caso&#8221; devido \u00e0s condi\u00e7\u00f5es de contacto e \u00e0 natureza dos meios de extra\u00e7\u00e3o. O objetivo do estudo \u00e9 a <strong>caracteriza\u00e7\u00e3o dos compostos extra\u00edveis<\/strong> que possam ser libertados dos tubos de silicone para a produ\u00e7\u00e3o farmac\u00eautica. Os extra\u00edveis ser\u00e3o caraterizados se estiverem presentes numa concentra\u00e7\u00e3o superior ao Limiar de Avalia\u00e7\u00e3o Anal\u00edtica (AET), calculado com base num Limiar de Preocupa\u00e7\u00e3o de Seguran\u00e7a (SCT) apropriado.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225072_b5d4bc-77, .wp-block-kadence-advancedheading.kt-adv-heading225072_b5d4bc-77[data-kb-block=\"kb-adv-heading225072_b5d4bc-77\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225072_b5d4bc-77 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225072_b5d4bc-77[data-kb-block=\"kb-adv-heading225072_b5d4bc-77\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225072_b5d4bc-77 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225072_b5d4bc-77[data-kb-block=\"kb-adv-heading225072_b5d4bc-77\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225072_b5d4bc-77 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225072_b5d4bc-77\"><strong>A estrat\u00e9gia da M\u00e9rieux NutriSciences para estudos de extra\u00edveis e lixivi\u00e1veis<\/strong><\/h2>\n\n\n\n<p>A seguran\u00e7a do produto farmac\u00eautico deve ser <strong>garantida em toda a cadeia de produ\u00e7\u00e3o<\/strong>, considerando tamb\u00e9m os componentes do sistema como parte integrante da abordagem do estudo:<\/p>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_7aac7d-99:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_7aac7d-99 ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_7aac7d-99 ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_7aac7d-99 ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items225072_7aac7d-99 ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items225072_7aac7d-99 kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-225072_51e27b-d8 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_51e27b-d8\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Estudos de Extra\u00edveis &amp; Lixivi\u00e1veis.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225072_1bcd4b-c7 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_1bcd4b-c7\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Avalia\u00e7\u00e3o toxicol\u00f3gica.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225072_8336f4-3d .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_8336f4-3d\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Identifica\u00e7\u00e3o de potenciais riscos para o medicamento.<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.kb-image225072_17c897-62 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<div class=\"wp-block-kadence-image kb-image225072_17c897-62\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"676\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2022\/04\/schema_el_website_resized-2.jpg\" alt=\"extra\u00edveis em tubos de silicone utilizados na produ\u00e7\u00e3o de produtos farmac\u00eauticos\" class=\"kb-img wp-image-16329\"\/><\/figure><\/div>\n\n\n\n<p>A an\u00e1lise das subst\u00e2ncias extra\u00eddas considerou tanto as mol\u00e9culas org\u00e2nicas como as inorg\u00e2nicas. As <strong>t\u00e9cnicas de despiste cromatogr\u00e1fico utilizadas s\u00e3o combinadas com m\u00e9todos de dete\u00e7\u00e3o altamente sens\u00edveis e de ponta<\/strong>, aplicadas da seguinte forma:<\/p>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_a1905d-90:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_a1905d-90 ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_a1905d-90 ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_a1905d-90 ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items225072_a1905d-90 ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items225072_a1905d-90 kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-225072_369f22-57 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_369f22-57\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>HS-GC\/MS<\/strong> \u2013 Cromatografia em fase gasosa de headspace acoplada a um detetor de espetrometria de massa.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225072_a94ca2-cc .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_a94ca2-cc\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>GC\/MS<\/strong> \u2013 Cromatografia em fase gasosa acoplada a um detetor de massa.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225072_d57de8-01 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_d57de8-01\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>HPLC\/HR-MS Q-Orbitrap<\/strong> \u2013 Cromatografia l\u00edquida de ultra desempenho acoplada a um detetor de massa de alta resolu\u00e7\u00e3o.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225072_a65316-92 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_a65316-92\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>ICP\/MS<\/strong> \u2013 Plasma acoplado indutivamente acoplado a um detetor de massa.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225072_be96e5-fb .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_be96e5-fb\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>IC<\/strong> \u2013 Cromat\u00f3grafo i\u00f3nico com detetor de condutividade.<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225072_579908-fd, .wp-block-kadence-advancedheading.kt-adv-heading225072_579908-fd[data-kb-block=\"kb-adv-heading225072_579908-fd\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225072_579908-fd mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225072_579908-fd[data-kb-block=\"kb-adv-heading225072_579908-fd\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225072_579908-fd img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225072_579908-fd[data-kb-block=\"kb-adv-heading225072_579908-fd\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225072_579908-fd wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225072_579908-fd\"><strong>Resultados<\/strong><\/h2>\n\n\n\n<p>Os resultados obtidos foram submetidos a uma avalia\u00e7\u00e3o toxicol\u00f3gica para estabelecer a seguran\u00e7a dos tubos ou a necessidade de investiga\u00e7\u00f5es adicionais.<\/p>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_8e9de0-6a:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_8e9de0-6a ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_8e9de0-6a ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225072_8e9de0-6a ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items225072_8e9de0-6a ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items225072_8e9de0-6a kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-225072_e492f6-a8 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_e492f6-a8\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Nenhuma impureza elementar estudada mostrou valores superiores ao limite de quantifica\u00e7\u00e3o, \u00e0 exce\u00e7\u00e3o do elemento boro.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225072_45ec79-57 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_45ec79-57\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Nenhum ani\u00e3o mostra valores superiores ao LOQ (Limite de Quantifica\u00e7\u00e3o) do m\u00e9todo.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225072_572096-f9 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225072_572096-f9\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Nenhum composto org\u00e2nico VOC, SVOC ou NVOC examinado nos meios de extra\u00e7\u00e3o estava presente numa concentra\u00e7\u00e3o igual ou superior ao AET .<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-225072_38901b-02 .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-225072_38901b-02 .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-225072_38901b-02\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns225072_6f4f4c-1c{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns225072_6f4f4c-1c .kt-button{font-weight:normal;font-style:normal;}.kt-btns225072_6f4f4c-1c .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns225072_6f4f4c-1c .kt-btn-wrap-0 .kt-button{color:#555555;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns225072_6f4f4c-1c .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns225072_6f4f4c-1c .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns225072_6f4f4c-1c .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns225072_6f4f4c-1c .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns225072_6f4f4c-1c .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns225072_6f4f4c-1c\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn225072_50cbad-da.kb-button{width:initial;}<\/style><a class=\"kb-button kt-button button kb-btn225072_50cbad-da kt-btn-size-standard kt-btn-width-type-auto kb-btn-global-fill  kt-btn-has-text-true kt-btn-has-svg-false  wp-block-kadence-singlebtn\" href=\"https:\/\/www.merieuxnutrisciences.com\/pt\/contacto\/\"><span class=\"kt-btn-inner-text\">Para mais informa\u00e7\u00f5es, contacte-nos<\/span><\/a><\/div>\n\n\n<div class=\"page-cards-block-wrapper fullwidth-block\">   \n    <div class=\"page-cards-title-container\"> \n        <h2>Servi\u00e7os relacionados<\/h2>    \n    <\/div>\n    <div class=\"full-width-row-page-cards-wrapper\">\n        <div class=\"page-cards-container\">\n                                            <a href=\"https:\/\/www.merieuxnutrisciences.com\/pt\/produtos-farmaceuticos-e-dispositivos-medicos\/produtos-farmaceuticos\/drug-containers-packaging\/\" class=\"card\">\n                                            <img decoding=\"async\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2024\/08\/Studi-sugli-Extractables-e-Leachables-per-lindustria-farmaceutica-blu.png\" alt=\"Extra\u00edveis e lixivi\u00e1veis e em embalagens farmac\u00eauticas\" class=\"card-icon\"\/>\n                                        <div class=\"card-content\">\n                        <span>Extra\u00edveis e lixivi\u00e1veis e em embalagens farmac\u00eauticas<\/span>\n                    <\/div>\n                <\/a>\n                                            <a href=\"https:\/\/www.merieuxnutrisciences.com\/pt\/produtos-farmaceuticos-e-dispositivos-medicos\/produtos-farmaceuticos\/\" class=\"card\">\n                                            <img decoding=\"async\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/medicine1.svg\" alt=\"Produtos farmac\u00eauticos\" class=\"card-icon\"\/>\n                                        <div class=\"card-content\">\n                        <span>Produtos farmac\u00eauticos<\/span>\n                    <\/div>\n                <\/a>\n                                <\/div>\n    <\/div>\n<\/div>    \n   \n\n<style>\n.fullwidth-block {\n    max-width: none !important;\n    width: 100vw !important;\n    position: relative;\n    padding:0px;\n    \/* left: 50%;\n    right: 50%;\n    margin-left: -50vw;\n    margin-right: -50vw; *\/\n}\n\n.page-cards-title-container{\n    max-width: 1290px;\n    margin: 100px auto 150px auto;\n    padding-left: var(--global-content-edge-padding);\n    padding-right: var(--global-content-edge-padding);\n}\n.page-cards-title-container h2{\n    color:var(--global-palette4);\n    text-align: center;\n}\n.full-width-row-page-cards-wrapper{\n    background-color: var(--global-palette4);\n}\n.page-cards-container{\n    max-width:1290px;\n    margin: 0 auto;\n    display: flex;\n    gap: 20px;\n    align-items: center;\n    justify-content: center;\n    padding: 0 12px;\n    flex-wrap: wrap;\n}\n.card {\n    display: flex;\n    transform: translate(0px, -100px);\n    flex-direction: column;\n    align-items: center;\n    justify-content: center;\n    width: 200px;\n    height: 200px;\n    background-color: white;\n    text-decoration: none;\n    color: black;\n    border: 1px solid #ccc;\n    padding: 10px;\n    box-shadow: 0 2px 5px rgba(0,0,0,0.1);\n    border-radius: 8px;\n    overflow: hidden;\n}\n\n.card-icon {\n    align-self: center;\n    width: 80px; \n    height: auto;\n    margin-bottom: 10px;\n}\n.card-content{\n    display:flex;\n    justify-content: center;\n}\n\n.card-content span{\n    color:var(--global-palette3);\n    text-align: center;\n    text-transform: uppercase;\n    margin: 5px 0;\n    line-height: 1.2em;\n    font-size: 16px;\n    font-weight:bold;\n}\n\n.card:hover {\n    animation: all ease-in-out 0.3s;\n    transform: scale(.95) translate(0px, -100px);\n    box-shadow: 0 4px 8px rgba(0,0,0,0.2);\n}\n\n@media (max-width: 767px) {\n    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uppercase;\n    font-size: 20px;\n    margin-bottom: 20px; \/* Space above the list *\/\n}\n\n.related-articles-block h2,\n.related-articles-block .related-articles-subtitle {\n    text-align: left;\n}\n\n.related-articles-block ul {\n    list-style: none;\n    padding: 0;\n    display: grid;\n    margin: 40px 0;\n    grid-template-columns: repeat(4, 1fr); \/* Four items per row *\/\n    gap: 20px; \/* Space between grid items *\/\n    justify-content: space-around; \/* Evenly space list items *\/\n    flex-wrap: wrap; \/* Allows items to wrap in small screens *\/\n   \n}\n\n.related-articles-block li {\n    background-color: #fff; \/* White background for list items *\/\n    padding: 15px;\n    margin: 10px;\n    width: calc(33.333% - 20px); \/* Three items per row minus margin *\/\n    box-shadow: 0 1px 3px rgba(0,0,0,0.1);\n    border-radius: 4px;\n    text-align: center; \/* Center-align text *\/\n    transition: transform 0.3s ease, box-shadow 0.3s ease; \/* Smooth transitions for hover effects *\/\n}\n\n.related-articles-block li a {\n    text-decoration: none;\n    color: #0073aa; \/* WordPress blue for links *\/\n    font-weight: bold;\n}\n\n.related-articles-block li:hover {\n    transform: translateY(-5px); \/* Slight lift effect on hover *\/\n    box-shadow: 0 4px 6px rgba(0,0,0,0.15);\n}\n.related-card {\n    display: block;\n    width: 100%; \/* Full width within grid item *\/\n    height: 300px;\n    background-color: #ffffff; \/* White background *\/\n    border: 1px solid #e0e0e0; \/* Light grey border *\/\n    border-radius: 8px; \/* Rounded corners *\/\n    text-decoration: none; \/* Removes underline from links *\/\n    color: #333333; \/* Dark grey text *\/\n    transition: all 0.3s ease; \/* Smooth transition for hover effects *\/\n    overflow: hidden; \/* Ensures no content spills outside the border *\/\n}\n\n.related-card-content {\n    padding: 16px; \/* Padding inside the card *\/\n    display: flex; \/* Flexbox to align content *\/\n    align-items: center; \/* Center items vertically *\/\n    justify-content: center; \/* Center content horizontally *\/\n    text-align: center; \/* Center text *\/\n}\n\n.related-card-content span {\n    font-size: 16px; \/* Font size for the title *\/\n    font-weight: bold; \/* Makes font bold *\/\n    color:var(--global-palette3);\n}\n\n.related-card:hover {\n    border-color: var(--global-palette4); \/* Changes border color on hover *\/\n    box-shadow: 0 4px 8px rgba(0, 0, 0, 0.1); \/* Subtle shadow for depth *\/\n    transform: translateY(-5px); \/* Slightly raise the card *\/\n}\n\n\/* Responsive adjustments for smaller screens *\/\n@media (max-width: 768px) {\n    .related-articles-block ul {\n        grid-template-columns: repeat(2, 1fr); \/* Two items per row on smaller screens *\/\n    }\n    .related-card-content {\n        padding: 12px; \/* Smaller padding on smaller screens *\/\n    }\n}\n@media (max-width: 480px) {\n    .related-articles-block ul {\n        grid-template-columns: 1fr; \/* One item per row on very small screens *\/\n    }\n    .related-articles-block h2,\n    .related-articles-block .related-articles-subtitle {\n        text-align: center;\n    }\n}\n<\/style>","protected":false},"excerpt":{"rendered":"<p>A nossa experi\u00eancia vai para al\u00e9m da embalagem.&nbsp; Os extra\u00edveis podem ter origem n\u00e3o s\u00f3 no sistema de embalagem do produto farmac\u00eautico, mas tamb\u00e9m nos sistemas e componentes utilizados durante o processo de produ\u00e7\u00e3o que entram em contacto com o medicamento antes da embalagem final. Os processos de produ\u00e7\u00e3o utilizam componentes e sistemas que podem&#8230;<\/p>\n","protected":false},"author":16,"featured_media":16343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[1754],"tags":[],"post_folder":[],"class_list":["post-225072","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-produtos-farmaceuticos"],"acf":[],"taxonomy_info":{"category":[{"value":1754,"label":"Produtos farmac\u00eauticos"}]},"featured_image_src_large":["https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2022\/04\/mxns_CardEL_3_Website_ENG_newsito.jpg",1024,299,false],"author_info":{"display_name":"Rui Nogueira","author_link":"https:\/\/www.merieuxnutrisciences.com\/pt\/author\/rui\/"},"comment_info":0,"category_info":[{"term_id":1754,"name":"Produtos farmac\u00eauticos","slug":"produtos-farmaceuticos","term_group":0,"term_taxonomy_id":1754,"taxonomy":"category","description":"","parent":0,"count":3,"filter":"raw","cat_ID":1754,"category_count":3,"category_description":"","cat_name":"Produtos farmac\u00eauticos","category_nicename":"produtos-farmaceuticos","category_parent":0}],"tag_info":false,"_links":{"self":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts\/225072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/comments?post=225072"}],"version-history":[{"count":5,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts\/225072\/revisions"}],"predecessor-version":[{"id":225098,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts\/225072\/revisions\/225098"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/media\/16343"}],"wp:attachment":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/media?parent=225072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/categories?post=225072"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/tags?post=225072"},{"taxonomy":"post_folder","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/post_folder?post=225072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}