{"id":225062,"date":"2024-11-08T13:59:00","date_gmt":"2024-11-08T13:59:00","guid":{"rendered":"https:\/\/www.merieuxnutrisciences.com\/?p=225062"},"modified":"2025-11-08T17:34:38","modified_gmt":"2025-11-08T17:34:38","slug":"embalagens-farmaceuticas-estudo-de-caso-sobre-extraiveis-e-lixiviaveis","status":"publish","type":"post","link":"https:\/\/www.merieuxnutrisciences.com\/pt\/embalagens-farmaceuticas-estudo-de-caso-sobre-extraiveis-e-lixiviaveis\/","title":{"rendered":"Embalagens farmac\u00eauticas: Estudo de caso sobre extra\u00edveis e lixivi\u00e1veis"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Tanto as embalagens prim\u00e1rias como as secund\u00e1rias utilizadas para produtos farmac\u00eauticos devem garantir a seguran\u00e7a do produto, proteg\u00ea-lo do ambiente e evitar a transfer\u00eancia de poss\u00edveis contaminantes nocivos para o medicamento at\u00e9 \u00e0 data de validade.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Os estudos sobre extra\u00edveis assumem, portanto, um papel central na elabora\u00e7\u00e3o do dossi\u00ea t\u00e9cnico para a entrada de produtos no mercado, bem como para uma avalia\u00e7\u00e3o do risco toxicol\u00f3gico da embalagem farmac\u00eautica e como refer\u00eancia para quaisquer estudos subsequentes de lixivi\u00e1veis.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225062_f142f6-e9, .wp-block-kadence-advancedheading.kt-adv-heading225062_f142f6-e9[data-kb-block=\"kb-adv-heading225062_f142f6-e9\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225062_f142f6-e9 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225062_f142f6-e9[data-kb-block=\"kb-adv-heading225062_f142f6-e9\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225062_f142f6-e9 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225062_f142f6-e9[data-kb-block=\"kb-adv-heading225062_f142f6-e9\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225062_f142f6-e9 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225062_f142f6-e9\"><strong>Como Garantir a Seguran\u00e7a?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A embalagem farmac\u00eautica em estudo refere-se <strong>a frascos ampolas blow-fill-seal \u2013 BFS em LDPE (Polietileno de Baixa Densidade) de 2,5 ml, que s\u00e3o utilizadas como embalagem prim\u00e1ria para produtos farmac\u00eauticos de inala\u00e7\u00e3o.<\/strong> A tecnologia BFS \u00e9 frequentemente utilizada para a produ\u00e7\u00e3o de recipientes cheios de l\u00edquidos, tanto para pequenos como para grandes volumes, e \u00e9 amplamente empregada na ind\u00fastria farmac\u00eautica. Geralmente, os recipientes BFS s\u00e3o feitos de polipropileno ou polietileno.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225062_f541cc-1b, .wp-block-kadence-advancedheading.kt-adv-heading225062_f541cc-1b[data-kb-block=\"kb-adv-heading225062_f541cc-1b\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225062_f541cc-1b mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225062_f541cc-1b[data-kb-block=\"kb-adv-heading225062_f541cc-1b\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225062_f541cc-1b img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225062_f541cc-1b[data-kb-block=\"kb-adv-heading225062_f541cc-1b\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225062_f541cc-1b wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225062_f541cc-1b\"><strong>Objetivo do Estudo<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">O objetivo do estudo \u00e9 a caracteriza\u00e7\u00e3o dos compostos extra\u00edveis que podem ser libertados dos frascos para uso farmac\u00eautico.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Os estudos de extra\u00e7\u00e3o s\u00e3o todos aqueles processos de laborat\u00f3rio necess\u00e1rios para criar perfis de extra\u00edveis a partir da embalagem. Os extra\u00edveis podem ser subst\u00e2ncias qu\u00edmicas de natureza org\u00e2nica ou inorg\u00e2nica libertadas do sistema de embalagem\/administra\u00e7\u00e3o farmac\u00eautico para um solvente de extra\u00e7\u00e3o sob condi\u00e7\u00f5es destinadas a submeter a embalagem a stress para al\u00e9m da sua utiliza\u00e7\u00e3o normal. As subst\u00e2ncias extra\u00edveis e os seus derivados podem ser libertados para o medicamento em condi\u00e7\u00f5es normais de conserva\u00e7\u00e3o e\/ou utiliza\u00e7\u00e3o, tornando-se assim lixivi\u00e1veis. Por esta raz\u00e3o, os perfis de extra\u00edveis podem ser utilizados para simular o pior cen\u00e1rio do perfil de lixivi\u00e1veis, que pode ser gerado no produto farmac\u00eautico embalado.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225062_95e8f8-46, .wp-block-kadence-advancedheading.kt-adv-heading225062_95e8f8-46[data-kb-block=\"kb-adv-heading225062_95e8f8-46\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225062_95e8f8-46 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225062_95e8f8-46[data-kb-block=\"kb-adv-heading225062_95e8f8-46\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225062_95e8f8-46 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225062_95e8f8-46[data-kb-block=\"kb-adv-heading225062_95e8f8-46\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225062_95e8f8-46 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225062_95e8f8-46\"><strong>Estrat\u00e9gia da M\u00e9rieux NutriSciences para Estudos de Extra\u00edveis &amp; Lixivi\u00e1veis<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Os produtos para inala\u00e7\u00e3o t\u00eam o mais alto n\u00edvel de risco, por isso os nossos especialistas desenvolveram uma estrat\u00e9gia de testes completa e integrada. Juntamente com uma avalia\u00e7\u00e3o toxicol\u00f3gica e uma an\u00e1lise de risco.<\/p>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items225062_5db9d9-9c:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225062_5db9d9-9c ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225062_5db9d9-9c ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225062_5db9d9-9c ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items225062_5db9d9-9c ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items225062_5db9d9-9c kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-225062_e40ee4-2a .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225062_e40ee4-2a\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Estudos de Extra\u00edveis &amp; L ixivi\u00e1veis<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225062_d295b0-63 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225062_d295b0-63\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Avalia\u00e7\u00e3o toxicol\u00f3gica\u00a0<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225062_3e4ef5-65 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225062_3e4ef5-65\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Identifica\u00e7\u00e3o de potenciais riscos para o medicamento<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading225062_fb507d-84, .wp-block-kadence-advancedheading.kt-adv-heading225062_fb507d-84[data-kb-block=\"kb-adv-heading225062_fb507d-84\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading225062_fb507d-84 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading225062_fb507d-84[data-kb-block=\"kb-adv-heading225062_fb507d-84\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading225062_fb507d-84 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading225062_fb507d-84[data-kb-block=\"kb-adv-heading225062_fb507d-84\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading225062_fb507d-84 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading225062_fb507d-84\"><strong>Resultados<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">O estudo anal\u00edtico, que pode ser considerado uma abordagem de &#8220;pior caso&#8221;, \u00e9 um apoio \u00fatil para a avalia\u00e7\u00e3o do risco de materiais em contacto com produtos farmac\u00eauticos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Os extratos obtidos foram analisados quanto a impurezas elementares, S-VOCs (compostos org\u00e2nicos semivol\u00e1teis), N-VOCs (compostos org\u00e2nicos n\u00e3o vol\u00e1teis) e ani\u00f5es, enquanto a embalagem tal como estava foi analisada quanto a VOCs (compostos org\u00e2nicos vol\u00e1teis). O estudo foi conduzido garantindo que os limites de quantifica\u00e7\u00e3o dos procedimentos anal\u00edticos respeitavam o AET (Analytical Evaluation Threshold), calculado com base num Limite de Preocupa\u00e7\u00e3o de Seguran\u00e7a oficialmente indicado para produtos farmac\u00eauticos de inala\u00e7\u00e3o.<\/p>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items225062_43b66c-ae:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225062_43b66c-ae ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225062_43b66c-ae ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items225062_43b66c-ae ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items225062_43b66c-ae ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items225062_43b66c-ae kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-225062_b3d56a-b3 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225062_b3d56a-b3\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Nenhum metal apresenta valores superiores ao LOQ do m\u00e9todo.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225062_658291-cf .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225062_658291-cf\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Nenhum ani\u00e3o apresenta valores superiores ao LOQ do m\u00e9todo.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-225062_7eb8e1-81 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-225062_7eb8e1-81\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">V\u00e1rios compostos org\u00e2nicos (VOC, SVOC, N-VOC) foram detetados em concentra\u00e7\u00f5es iguais ou superiores ao AET.<\/span><\/li>\n<\/ul><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Os resultados obtidos foram submetidos a uma avalia\u00e7\u00e3o toxicol\u00f3gica para determinar a seguran\u00e7a da embalagem ou a necessidade de investiga\u00e7\u00f5es adicionais.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-225062_cae59d-c9 .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-225062_cae59d-c9 .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-225062_cae59d-c9\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns225062_2f3815-c8{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns225062_2f3815-c8 .kt-button{font-weight:normal;font-style:normal;}.kt-btns225062_2f3815-c8 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns225062_2f3815-c8 .kt-btn-wrap-0 .kt-button{color:#555555;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns225062_2f3815-c8 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns225062_2f3815-c8 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns225062_2f3815-c8 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns225062_2f3815-c8 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns225062_2f3815-c8 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns225062_2f3815-c8\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn225062_92ca0c-2c.kb-button{width:initial;}<\/style><a class=\"kb-button kt-button button kb-btn225062_92ca0c-2c kt-btn-size-standard kt-btn-width-type-auto kb-btn-global-fill kt-btn-has-text-true kt-btn-has-svg-false wp-block-kadence-singlebtn\" href=\"https:\/\/www.merieuxnutrisciences.com\/pt\/contacto\/\"><span class=\"kt-btn-inner-text\">Para mais informa\u00e7\u00f5es, contacte-nos<\/span><\/a><\/div>\n\n\n<div class=\"page-cards-block-wrapper fullwidth-block\">   \n    <div class=\"page-cards-title-container\"> \n        <h2>Servi\u00e7os relacionados<\/h2>    \n    <\/div>\n    <div class=\"full-width-row-page-cards-wrapper\">\n        <div class=\"page-cards-container\">\n                                            <a href=\"https:\/\/www.merieuxnutrisciences.com\/pt\/produtos-farmaceuticos-e-dispositivos-medicos\/produtos-farmaceuticos\/drug-containers-packaging\/\" class=\"card\">\n                                            <img decoding=\"async\" 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hover effects *\/\n}\n\n.related-articles-block li a {\n    text-decoration: none;\n    color: #0073aa; \/* WordPress blue for links *\/\n    font-weight: bold;\n}\n\n.related-articles-block li:hover {\n    transform: translateY(-5px); \/* Slight lift effect on hover *\/\n    box-shadow: 0 4px 6px rgba(0,0,0,0.15);\n}\n.related-card {\n    display: block;\n    width: 100%; \/* Full width within grid item *\/\n    height: 300px;\n    background-color: #ffffff; \/* White background *\/\n    border: 1px solid #e0e0e0; \/* Light grey border *\/\n    border-radius: 8px; \/* Rounded corners *\/\n    text-decoration: none; \/* Removes underline from links *\/\n    color: #333333; \/* Dark grey text *\/\n    transition: all 0.3s ease; \/* Smooth transition for hover effects *\/\n    overflow: hidden; \/* Ensures no content spills outside the border *\/\n}\n\n.related-card-content {\n    padding: 16px; \/* Padding inside the card *\/\n    display: flex; \/* Flexbox to align content *\/\n    align-items: center; \/* Center items vertically *\/\n    justify-content: center; \/* Center content horizontally *\/\n    text-align: center; \/* Center text *\/\n}\n\n.related-card-content span {\n    font-size: 16px; \/* Font size for the title *\/\n    font-weight: bold; \/* Makes font bold *\/\n    color:var(--global-palette3);\n}\n\n.related-card:hover {\n    border-color: var(--global-palette4); \/* Changes border color on hover *\/\n    box-shadow: 0 4px 8px rgba(0, 0, 0, 0.1); \/* Subtle shadow for depth *\/\n    transform: translateY(-5px); \/* Slightly raise the card *\/\n}\n\n\/* Responsive adjustments for smaller screens *\/\n@media (max-width: 768px) {\n    .related-articles-block ul {\n        grid-template-columns: repeat(2, 1fr); \/* Two items per row on smaller screens *\/\n    }\n    .related-card-content {\n        padding: 12px; \/* Smaller padding on smaller screens *\/\n    }\n}\n@media (max-width: 480px) {\n    .related-articles-block ul {\n        grid-template-columns: 1fr; \/* One item per row on very small screens *\/\n    }\n    .related-articles-block h2,\n    .related-articles-block .related-articles-subtitle {\n        text-align: center;\n    }\n}\n<\/style>","protected":false},"excerpt":{"rendered":"<p>Tanto as embalagens prim\u00e1rias como as secund\u00e1rias utilizadas para produtos farmac\u00eauticos devem garantir a seguran\u00e7a do produto, proteg\u00ea-lo do ambiente e evitar a transfer\u00eancia de poss\u00edveis contaminantes nocivos para o medicamento at\u00e9 \u00e0 data de validade. Os estudos sobre extra\u00edveis assumem, portanto, um papel central na elabora\u00e7\u00e3o do dossi\u00ea t\u00e9cnico para a entrada de produtos&#8230;<\/p>\n","protected":false},"author":16,"featured_media":50392,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[1754],"tags":[1756,1755],"post_folder":[],"class_list":["post-225062","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-produtos-farmaceuticos","tag-embalagens-para-produtos-farmaceuticos","tag-produtos-farmaceuticos"],"acf":[],"taxonomy_info":{"category":[{"value":1754,"label":"Produtos farmac\u00eauticos"}],"post_tag":[{"value":1756,"label":"Embalagens para produtos farmac\u00eauticos"},{"value":1755,"label":"Produtos farmac\u00eauticos"}]},"featured_image_src_large":["https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2022\/02\/volodymyr-hryshchenko-m1Hq4ibP9rc-unsplash.jpg",1024,353,false],"author_info":{"display_name":"Rui Nogueira","author_link":"https:\/\/www.merieuxnutrisciences.com\/pt\/author\/rui\/"},"comment_info":0,"category_info":[{"term_id":1754,"name":"Produtos farmac\u00eauticos","slug":"produtos-farmaceuticos","term_group":0,"term_taxonomy_id":1754,"taxonomy":"category","description":"","parent":0,"count":3,"filter":"raw","cat_ID":1754,"category_count":3,"category_description":"","cat_name":"Produtos farmac\u00eauticos","category_nicename":"produtos-farmaceuticos","category_parent":0}],"tag_info":[{"term_id":1756,"name":"Embalagens para produtos farmac\u00eauticos","slug":"embalagens-para-produtos-farmaceuticos","term_group":0,"term_taxonomy_id":1756,"taxonomy":"post_tag","description":"","parent":0,"count":1,"filter":"raw"},{"term_id":1755,"name":"Produtos farmac\u00eauticos","slug":"produtos-farmaceuticos","term_group":0,"term_taxonomy_id":1755,"taxonomy":"post_tag","description":"","parent":0,"count":1,"filter":"raw"}],"_links":{"self":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts\/225062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/comments?post=225062"}],"version-history":[{"count":3,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts\/225062\/revisions"}],"predecessor-version":[{"id":225085,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/posts\/225062\/revisions\/225085"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/media\/50392"}],"wp:attachment":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/media?parent=225062"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/categories?post=225062"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/tags?post=225062"},{"taxonomy":"post_folder","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/post_folder?post=225062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}