{"id":223993,"date":"2025-11-07T23:26:02","date_gmt":"2025-11-07T23:26:02","guid":{"rendered":"https:\/\/www.merieuxnutrisciences.com\/?page_id=223993"},"modified":"2025-11-08T00:27:29","modified_gmt":"2025-11-08T00:27:29","slug":"estudos-de-absorcao-para-produtos-farmaceuticos","status":"publish","type":"page","link":"https:\/\/www.merieuxnutrisciences.com\/pt\/produtos-farmaceuticos-e-dispositivos-medicos\/produtos-farmaceuticos\/estudos-de-absorcao-para-produtos-farmaceuticos\/","title":{"rendered":"Estudos de absor\u00e7\u00e3o para produtos farmac\u00eauticos"},"content":{"rendered":"\n<div class=\"page-header-block-wrapper fullwidth-block\">\n    <div class=\"acf-page-header\" style=\"background-image: url('https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2024\/09\/shutterstock_744413632_Extractables-and-leachables.jpg'); \">\n        <div class=\"overlay\"><\/div>\n        <div class=\"acf-page-header-container\">\n                            <div class=\"image-wrapper\">\n                    <img decoding=\"async\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/studi-assorbiento-1.png\" alt=\"Icon\" \/>\n                <\/div>\n                        <h1>Estudos de absor\u00e7\u00e3o para produtos farmac\u00eauticos<\/h1>\n        <\/div>\n    <\/div>\n<\/div>\n\n<style>\n.page-header-block-wrapper{\n    margin-bottom: 60px;\n}\n\n.fullwidth-block {\n    max-width: none !important;\n    width: 100vw !important;\n    position: relative;\n    padding:0px;\n    left: 50%;\n    right: 50%;\n    margin-left: -50vw;\n    margin-right: -50vw;\n}\n\n.acf-page-header {\n    background-size: cover;\n    background-position: center;\n    display: flex;\n    position: relative;\n    min-height: 250px; \n}\n\n.acf-page-header-container{\n    margin: 0 auto;\n    padding: 48px 24px;\n    display: flex;\n    flex-direction: column;\n    justify-content: end;\n    align-items: center;\n}\n\n.acf-page-header .overlay {\n    position: absolute;\n    top: 0;\n    left: 0;\n    right: 0;\n    bottom: 0;\n    background: linear-gradient(to top, var(--global-palette4), transparent);\n    z-index: 1;\n}\n\n.acf-page-header-container .image-wrapper{\n    position:relative;\n    height: 70px;\n    width: 70px;\n    background: var(--global-palette4);\n    border-radius: 50%;\n    z-index: 1;\n}\n\n.acf-page-header-container img{\n    position: absolute;\n    top: 50%;\n    left: 50%;\n    transform: translate(-50%, -50%);\n    max-width:40px;\n    z-index: 2;\n}\n\n.acf-page-header h1 {\n    display:block;\n    position: relative;\n    z-index: 2;\n    color:white;\n    text-align: center;\n}\n\n@media (min-width: 1025px) {\n    .acf-page-header-container{\n        width: 1290px;\n    }\n    \n}\n\n@media (max-width: 1024px) {\n    .acf-page-header-container {\n        align-self: end;\n    }\n    .acf-page-header .overlay {\n        background: linear-gradient(to top, var(--global-palette4), transparent);\n    }\n}\n\n@media (max-width: 768px) {\n    .acf-page-header .overlay {\n        background: linear-gradient(to top, var(--global-palette4), transparent);\n    }\n    .acf-page-header h1 {\n        font-size:28px;\n    }\n}\n\n<\/style>\n\n\n\n\n<p class=\"wp-block-paragraph\"><strong>O ECSIN LAB,<\/strong> com sede em It\u00e1lia e parte do grupo M\u00e9rieux NutriSciences, \u00e9 um laborat\u00f3rio de inova\u00e7\u00e3o que <strong>une o foco na efic\u00e1cia das solu\u00e7\u00f5es propostas com a participa\u00e7\u00e3o em projetos cient\u00edficos estrat\u00e9gicos internacionais para o futuro.<\/strong><\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_8969a0-e4, .wp-block-kadence-advancedheading.kt-adv-heading223993_8969a0-e4[data-kb-block=\"kb-adv-heading223993_8969a0-e4\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_8969a0-e4 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_8969a0-e4[data-kb-block=\"kb-adv-heading223993_8969a0-e4\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_8969a0-e4 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_8969a0-e4[data-kb-block=\"kb-adv-heading223993_8969a0-e4\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading223993_8969a0-e4 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_8969a0-e4\">O nosso laborat\u00f3rio<\/h2>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_b53a6e-65, .wp-block-kadence-advancedheading.kt-adv-heading223993_b53a6e-65[data-kb-block=\"kb-adv-heading223993_b53a6e-65\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_b53a6e-65 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_b53a6e-65[data-kb-block=\"kb-adv-heading223993_b53a6e-65\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_b53a6e-65 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_b53a6e-65[data-kb-block=\"kb-adv-heading223993_b53a6e-65\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_b53a6e-65 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_b53a6e-65\"><strong>Informa\u00e7\u00f5es principais<\/strong><\/h3>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_ff81b3-29:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_ff81b3-29 ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_ff81b3-29 ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_ff81b3-29 ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items223993_ff81b3-29 ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items223993_ff81b3-29 kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-223993_fb9fcb-6f .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_fb9fcb-6f\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Equipa de investigadores altamente qualificados.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_dca185-34 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_dca185-34\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Participa\u00e7\u00e3o em grupos de trabalho nacionais e internacionais.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_d45d1b-cd .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_d45d1b-cd\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Participa\u00e7\u00e3o em projetos estrat\u00e9gicos nacionais e internacionais.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_148146-1a .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_148146-1a\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Publica\u00e7\u00f5es cient\u00edficas.<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_f73b4e-31, .wp-block-kadence-advancedheading.kt-adv-heading223993_f73b4e-31[data-kb-block=\"kb-adv-heading223993_f73b4e-31\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_f73b4e-31 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_f73b4e-31[data-kb-block=\"kb-adv-heading223993_f73b4e-31\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_f73b4e-31 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_f73b4e-31[data-kb-block=\"kb-adv-heading223993_f73b4e-31\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_f73b4e-31 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_f73b4e-31\"><strong>Capacidade<\/strong><\/h3>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_1a339b-9b:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_1a339b-9b ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_1a339b-9b ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_1a339b-9b ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items223993_1a339b-9b ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items223993_1a339b-9b kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-223993_c480c1-03 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_c480c1-03\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Dete\u00e7\u00e3o e identifica\u00e7\u00e3o de <strong>micropl\u00e1sticos<\/strong>.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_b12a35-ae .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_b12a35-ae\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Identifica\u00e7\u00e3o e caracteriza\u00e7\u00e3o de <strong>nanomateriais.<\/strong><\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_69ae18-cd .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_69ae18-cd\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><strong>Novos Alimentos:<\/strong> toda a cadeia de valor nos nossos laborat\u00f3rios.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_538ad9-b5 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_538ad9-b5\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Estudos de permea\u00e7\u00e3o, absor\u00e7\u00e3o e efic\u00e1cia <em>in vitro<\/em>.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_a50128-fe .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_a50128-fe\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Projetos personalizados dedicados (<em>on demand<\/em>).<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_ed7544-05, .wp-block-kadence-advancedheading.kt-adv-heading223993_ed7544-05[data-kb-block=\"kb-adv-heading223993_ed7544-05\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_ed7544-05 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_ed7544-05[data-kb-block=\"kb-adv-heading223993_ed7544-05\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_ed7544-05 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_ed7544-05[data-kb-block=\"kb-adv-heading223993_ed7544-05\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_ed7544-05 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_ed7544-05\"><strong>Acredita\u00e7\u00f5es<\/strong><\/h3>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_f63390-9f:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_f63390-9f ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_f63390-9f ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_f63390-9f ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items223993_f63390-9f ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items223993_f63390-9f kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-223993_96c175-60 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_96c175-60\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">An\u00e1lise de micropl\u00e1sticos: primeiro laborat\u00f3rio acreditado para alimentos, ra\u00e7\u00f5es e \u00e1guas.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_aed1a1-3f .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_aed1a1-3f\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">An\u00e1lise de nanomateriais: TEM, BET, picnometria e DLS acreditados para mais de 15 an\u00e1lises.<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-223993_ac7351-fd .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-223993_ac7351-fd .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-223993_ac7351-fd\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_c6c6e7-32, .wp-block-kadence-advancedheading.kt-adv-heading223993_c6c6e7-32[data-kb-block=\"kb-adv-heading223993_c6c6e7-32\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_c6c6e7-32 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_c6c6e7-32[data-kb-block=\"kb-adv-heading223993_c6c6e7-32\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_c6c6e7-32 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_c6c6e7-32[data-kb-block=\"kb-adv-heading223993_c6c6e7-32\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading223993_c6c6e7-32 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_c6c6e7-32\">Refer\u00eancias regulamentares<\/h2>\n\n\n<style>.kt-accordion-id223993_4f8fa9-14 .kt-accordion-inner-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:0px;}.kt-accordion-id223993_4f8fa9-14 .kt-accordion-panel-inner{border-top:0px solid transparent;border-right:0px solid transparent;border-bottom:0px solid transparent;border-left:0px solid transparent;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-right:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);padding-left:var(--global-kb-spacing-sm, 1.5rem);}.kt-accordion-id223993_4f8fa9-14 > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header{border-top:1px solid #f2f2f2;border-right:1px solid #f2f2f2;border-bottom:1px solid #f2f2f2;border-left:1px solid #f2f2f2;border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;background:#f2f2f2;color:#555555;padding-top:9px;padding-right:13px;padding-bottom:9px;padding-left:13px;}.kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle )  > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle )  > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap .kt-blocks-accordion-icon-trigger:before{background:#555555;}.kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-icon-trigger{background:#555555;}.kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-icon-trigger:before{background:#f2f2f2;}.kt-accordion-id223993_4f8fa9-14 > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header:hover, \n\t\t\t\tbody:not(.hide-focus-outline) .kt-accordion-id223993_4f8fa9-14 .kt-blocks-accordion-header:focus-visible{color:#444444;background:#eeeeee;border-top:1px solid #878787;border-right:1px solid #878787;border-bottom:1px solid #878787;border-left:1px solid #878787;}.kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle ) .kt-accordion-header-wrap .kt-blocks-accordion-header:hover .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle ) .kt-accordion-header-wrap .kt-blocks-accordion-header:hover .kt-blocks-accordion-icon-trigger:before, body:not(.hide-focus-outline) .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle ) .kt-blocks-accordion--visible .kt-blocks-accordion-icon-trigger:after, body:not(.hide-focus-outline) .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle ) .kt-blocks-accordion-header:focus-visible .kt-blocks-accordion-icon-trigger:before{background:#444444;}.kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:hover .kt-blocks-accordion-icon-trigger, body:not(.hide-focus-outline) .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible .kt-blocks-accordion-icon-trigger{background:#444444;}.kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:hover .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:hover .kt-blocks-accordion-icon-trigger:before, body:not(.hide-focus-outline) .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible .kt-blocks-accordion-icon-trigger:after, body:not(.hide-focus-outline) .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible .kt-blocks-accordion-icon-trigger:before{background:#eeeeee;}.kt-accordion-id223993_4f8fa9-14 .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible,\n\t\t\t\t.kt-accordion-id223993_4f8fa9-14 > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header.kt-accordion-panel-active{color:#ffffff;background:#444444;border-top:1px solid #444444;border-right:1px solid #444444;border-bottom:1px solid #444444;border-left:1px solid #444444;}.kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle )  > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle )  > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger:before{background:#ffffff;}.kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger{background:#ffffff;}.kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_4f8fa9-14:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger:before{background:#444444;}@media all and (max-width: 1024px){.kt-accordion-id223993_4f8fa9-14 .kt-accordion-panel-inner{border-top:0px solid transparent;border-right:0px solid transparent;border-bottom:0px solid transparent;border-left:0px solid transparent;}}@media all and (max-width: 1024px){.kt-accordion-id223993_4f8fa9-14 > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header{border-top:1px solid #f2f2f2;border-right:1px solid #f2f2f2;border-bottom:1px solid #f2f2f2;border-left:1px solid #f2f2f2;}}@media all and (max-width: 1024px){.kt-accordion-id223993_4f8fa9-14 > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header:hover, \n\t\t\t\tbody:not(.hide-focus-outline) .kt-accordion-id223993_4f8fa9-14 .kt-blocks-accordion-header:focus-visible{border-top:1px solid #878787;border-right:1px solid #878787;border-bottom:1px solid #878787;border-left:1px solid #878787;}}@media all and (max-width: 1024px){.kt-accordion-id223993_4f8fa9-14 .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible,\n\t\t\t\t.kt-accordion-id223993_4f8fa9-14 > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header.kt-accordion-panel-active{border-top:1px solid #444444;border-right:1px solid #444444;border-bottom:1px solid #444444;border-left:1px solid #444444;}}@media all and (max-width: 767px){.kt-accordion-id223993_4f8fa9-14 .kt-accordion-inner-wrap{display:block;}.kt-accordion-id223993_4f8fa9-14 .kt-accordion-inner-wrap .kt-accordion-pane:not(:first-child){margin-top:0px;}.kt-accordion-id223993_4f8fa9-14 .kt-accordion-panel-inner{border-top:0px solid transparent;border-right:0px solid transparent;border-bottom:0px solid transparent;border-left:0px solid transparent;}.kt-accordion-id223993_4f8fa9-14 > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header{border-top:1px solid #f2f2f2;border-right:1px solid #f2f2f2;border-bottom:1px solid #f2f2f2;border-left:1px solid #f2f2f2;}.kt-accordion-id223993_4f8fa9-14 > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header:hover, \n\t\t\t\tbody:not(.hide-focus-outline) .kt-accordion-id223993_4f8fa9-14 .kt-blocks-accordion-header:focus-visible{border-top:1px solid #878787;border-right:1px solid #878787;border-bottom:1px solid #878787;border-left:1px solid #878787;}.kt-accordion-id223993_4f8fa9-14 .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible,\n\t\t\t\t.kt-accordion-id223993_4f8fa9-14 > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header.kt-accordion-panel-active{border-top:1px solid #444444;border-right:1px solid #444444;border-bottom:1px solid #444444;border-left:1px solid #444444;}}<\/style>\n<div class=\"wp-block-kadence-accordion alignnone\"><div class=\"kt-accordion-wrap kt-accordion-id223993_4f8fa9-14 kt-accordion-has-3-panes kt-active-pane-0 kt-accordion-block kt-pane-header-alignment-left kt-accodion-icon-style-basic kt-accodion-icon-side-right\" style=\"max-width:none\"><div class=\"kt-accordion-inner-wrap\" data-allow-multiple-open=\"false\" data-start-open=\"none\">\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-1 kt-pane223993_a69eb4-6c\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\"><strong>Estudos de absor\u00e7\u00e3o e efic\u00e1cia in vitro<\/strong><\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\"><style>.wp-block-kadence-advancedheading.kt-adv-heading223993_e3786e-72, .wp-block-kadence-advancedheading.kt-adv-heading223993_e3786e-72[data-kb-block=\"kb-adv-heading223993_e3786e-72\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_e3786e-72 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_e3786e-72[data-kb-block=\"kb-adv-heading223993_e3786e-72\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_e3786e-72 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_e3786e-72[data-kb-block=\"kb-adv-heading223993_e3786e-72\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_e3786e-72 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_e3786e-72\"><strong>Estudos de Absor\u00e7\u00e3o e Efic\u00e1cia in vitro<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Os modelos <em>in vitro<\/em> que imitam diversas barreiras biol\u00f3gicas podem ser adotados para realizar estudos de absor\u00e7\u00e3o e avaliar a efic\u00e1cia de produtos, ingredientes ou novas formula\u00e7\u00f5es antes de avan\u00e7ar para a fase seguinte de avalia\u00e7\u00e3o (por exemplo, os ensaios cl\u00ednicos).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Os m\u00e9todos <em>in vitro<\/em> s\u00e3o menos dispendiosos, mais r\u00e1pidos e oferecem um melhor controlo das vari\u00e1veis experimentais em compara\u00e7\u00e3o com os estudos em humanos ou em animais. Por isso, podem ser facilmente utilizados como ferramenta de triagem, classifica\u00e7\u00e3o ou categoriza\u00e7\u00e3o.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_11e56c-57, .wp-block-kadence-advancedheading.kt-adv-heading223993_11e56c-57[data-kb-block=\"kb-adv-heading223993_11e56c-57\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_11e56c-57 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_11e56c-57[data-kb-block=\"kb-adv-heading223993_11e56c-57\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_11e56c-57 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_11e56c-57[data-kb-block=\"kb-adv-heading223993_11e56c-57\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_11e56c-57 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_11e56c-57\"><strong>Porqu\u00ea escolher modelos <\/strong><strong><em>in vitro<\/em><\/strong><strong>?<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reduzir custos e tempo.<\/li>\n\n\n\n<li>Avaliar o desempenho do produto de forma mais direta:\n<ul class=\"wp-block-list\">\n<li>Sele\u00e7\u00e3o dos melhores <em>endpoints<\/em> a investigar com estudos cl\u00ednicos.<\/li>\n\n\n\n<li>Definir a posologia.<\/li>\n\n\n\n<li>Selecionar o prot\u00f3tipo\/formula\u00e7\u00e3o mais promissora.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_ffc03e-7b, .wp-block-kadence-advancedheading.kt-adv-heading223993_ffc03e-7b[data-kb-block=\"kb-adv-heading223993_ffc03e-7b\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_ffc03e-7b mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_ffc03e-7b[data-kb-block=\"kb-adv-heading223993_ffc03e-7b\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_ffc03e-7b img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_ffc03e-7b[data-kb-block=\"kb-adv-heading223993_ffc03e-7b\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_ffc03e-7b wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_ffc03e-7b\"><strong>Que tipo de estudos?<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Investiga\u00e7\u00e3o do modo de a\u00e7\u00e3o dos princ\u00edpios ativos para apoiar patentes e publica\u00e7\u00f5es cient\u00edficas\/de <em>marketing<\/em>.<\/li>\n\n\n\n<li><strong>Bioacessibilidade:<\/strong> Fra\u00e7\u00e3o do princ\u00edpio ativo libertado do produto durante a digest\u00e3o gastrointestinal e dispon\u00edvel para absor\u00e7\u00e3o.<\/li>\n\n\n\n<li><strong>Biodisponibilidade:<\/strong> Fra\u00e7\u00e3o do princ\u00edpio ativo absorvida pelo organismo e capaz de atingir a circula\u00e7\u00e3o sangu\u00ednea.<\/li>\n\n\n\n<li><strong>Efic\u00e1cia:<\/strong> Capacidade de um princ\u00edpio ativo de desempenhar a sua fun\u00e7\u00e3o num tecido biol\u00f3gico.<\/li>\n\n\n\n<li><strong>Seguran\u00e7a:<\/strong> As formula\u00e7\u00f5es e\/ou os princ\u00edpios ativos n\u00e3o devem ter efeitos negativos nos tecidos biol\u00f3gicos.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-2 kt-pane223993_4f50c6-c5\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\"><strong>Biowaivers: Regulamentos sobre medicamentos bioequivalentes<\/strong><\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\"><style>.wp-block-kadence-advancedheading.kt-adv-heading223993_925d8e-a2, .wp-block-kadence-advancedheading.kt-adv-heading223993_925d8e-a2[data-kb-block=\"kb-adv-heading223993_925d8e-a2\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_925d8e-a2 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_925d8e-a2[data-kb-block=\"kb-adv-heading223993_925d8e-a2\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_925d8e-a2 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_925d8e-a2[data-kb-block=\"kb-adv-heading223993_925d8e-a2\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_925d8e-a2 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_925d8e-a2\"><strong>System-based Biowaivers &#8211; Diretriz sobre classifica\u00e7\u00e3o biofarmac\u00eautica<\/strong> <strong>EMA\/ICH M9<\/strong>, FDA M9<\/h3>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_7ee1f3-8a, .wp-block-kadence-advancedheading.kt-adv-heading223993_7ee1f3-8a[data-kb-block=\"kb-adv-heading223993_7ee1f3-8a\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_7ee1f3-8a mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_7ee1f3-8a[data-kb-block=\"kb-adv-heading223993_7ee1f3-8a\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_7ee1f3-8a img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_7ee1f3-8a[data-kb-block=\"kb-adv-heading223993_7ee1f3-8a\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_7ee1f3-8a wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_7ee1f3-8a\"><strong>Resumo:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Este documento fornece diretrizes sobre os <a href=\"https:\/\/database.ich.org\/sites\/default\/files\/M9_Guideline_Step4_2019_1116.pdf\" target=\"_blank\" data-type=\"link\" data-id=\"chrome-extension:\/\/efaidnbmnnnibpcajpcglclefindmkaj\/https:\/\/database.ich.org\/sites\/default\/files\/M9_Guideline_Step4_2019_1116.pdf\" rel=\"noreferrer noopener\"><em>Biowaivers<\/em> baseados no Sistema de Classifica\u00e7\u00e3o Biofarmac\u00eautica<\/a>.<\/li>\n\n\n\n<li>Concentra-se em m\u00e9todos para apoiar a classifica\u00e7\u00e3o das subst\u00e2ncias farmacol\u00f3gicas e justificar a bioequival\u00eancia sem estudos <em>in vivo<\/em>, garantindo coer\u00eancia em termos de seguran\u00e7a e efic\u00e1cia.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_937943-f7, .wp-block-kadence-advancedheading.kt-adv-heading223993_937943-f7[data-kb-block=\"kb-adv-heading223993_937943-f7\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_937943-f7 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_937943-f7[data-kb-block=\"kb-adv-heading223993_937943-f7\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_937943-f7 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_937943-f7[data-kb-block=\"kb-adv-heading223993_937943-f7\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_937943-f7 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_937943-f7\"><strong>\u00c2mbito do documento:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aplic\u00e1vel a <strong>formas farmac\u00eauticas s\u00f3lidas de liberta\u00e7\u00e3o imediata administradas por via oral ou suspens\u00f5es.<\/strong><\/li>\n\n\n\n<li>Relevante para altera\u00e7\u00f5es p\u00f3s-aprova\u00e7\u00e3o, pedidos de medicamentos gen\u00e9ricos e produtos utilizados durante o desenvolvimento cl\u00ednico.<\/li>\n\n\n\n<li>Exclui os produtos farmac\u00eauticos com um \u00edndice terap\u00eautico restrito e aqueles que requerem estudos cl\u00ednicos espec\u00edficos de bioequival\u00eancia.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_0aecd3-a8, .wp-block-kadence-advancedheading.kt-adv-heading223993_0aecd3-a8[data-kb-block=\"kb-adv-heading223993_0aecd3-a8\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_0aecd3-a8 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_0aecd3-a8[data-kb-block=\"kb-adv-heading223993_0aecd3-a8\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_0aecd3-a8 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_0aecd3-a8[data-kb-block=\"kb-adv-heading223993_0aecd3-a8\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_0aecd3-a8 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_0aecd3-a8\"><strong>M\u00e9todo CaCO<\/strong><strong><sub>2<\/sub><\/strong><strong> PERMEABILITY ASSAY<\/strong><\/h3>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_95cb8c-1b, .wp-block-kadence-advancedheading.kt-adv-heading223993_95cb8c-1b[data-kb-block=\"kb-adv-heading223993_95cb8c-1b\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_95cb8c-1b mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_95cb8c-1b[data-kb-block=\"kb-adv-heading223993_95cb8c-1b\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_95cb8c-1b img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_95cb8c-1b[data-kb-block=\"kb-adv-heading223993_95cb8c-1b\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_95cb8c-1b wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_95cb8c-1b\"><strong>\u00c2mbito e Aplica\u00e7\u00e3o:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Estima a absor\u00e7\u00e3o intestinal de medicamentos usando monoculturas de c\u00e9lulas epiteliais CaCO<sub>2<\/sub>.<\/li>\n\n\n\n<li>Validado para o transporte passivo de medicamentos para apoiar a classifica\u00e7\u00e3o BCS, em particular para medicamentos de alta permeabilidade.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_151cc0-dd, .wp-block-kadence-advancedheading.kt-adv-heading223993_151cc0-dd[data-kb-block=\"kb-adv-heading223993_151cc0-dd\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_151cc0-dd mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_151cc0-dd[data-kb-block=\"kb-adv-heading223993_151cc0-dd\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_151cc0-dd img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_151cc0-dd[data-kb-block=\"kb-adv-heading223993_151cc0-dd\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_151cc0-dd wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_151cc0-dd\"><strong>Valida\u00e7\u00e3o e Fiabilidade:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A valida\u00e7\u00e3o do m\u00e9todo deve incluir uma rela\u00e7\u00e3o de ordem de hierarquia entre a permeabilidade e a extens\u00e3o da absor\u00e7\u00e3o humana.<\/li>\n\n\n\n<li>Requer m\u00faltiplas r\u00e9plicas e modelo de medicamentos para garantir a fiabilidade e a coer\u00eancia dos resultados.<\/li>\n\n\n\n<li>Demonstra a independ\u00eancia do ensaio dos mecanismos de transporte ativo para uma classifica\u00e7\u00e3o precisa da permeabilidade.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_71a9ae-e7, .wp-block-kadence-advancedheading.kt-adv-heading223993_71a9ae-e7[data-kb-block=\"kb-adv-heading223993_71a9ae-e7\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_71a9ae-e7 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_71a9ae-e7[data-kb-block=\"kb-adv-heading223993_71a9ae-e7\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_71a9ae-e7 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_71a9ae-e7[data-kb-block=\"kb-adv-heading223993_71a9ae-e7\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_71a9ae-e7 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_71a9ae-e7\"><strong>System-based Biowaivers- Diretriz FDA M9<\/strong><\/h3>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_e25821-95, .wp-block-kadence-advancedheading.kt-adv-heading223993_e25821-95[data-kb-block=\"kb-adv-heading223993_e25821-95\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_e25821-95 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_e25821-95[data-kb-block=\"kb-adv-heading223993_e25821-95\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_e25821-95 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_e25821-95[data-kb-block=\"kb-adv-heading223993_e25821-95\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_e25821-95 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_e25821-95\"><strong>Resumo:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Este documento fornece diretrizes sobre os <strong><em>biowaivers<\/em> baseados no<\/strong> <a href=\"https:\/\/www.fda.gov\/media\/148472\/download\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/www.fda.gov\/media\/148472\/download\" rel=\"noreferrer noopener\">Sistema de Classifica\u00e7\u00e3o Biofarmac\u00eautica (BCS)<\/a>. <\/li>\n\n\n\n<li>Concentra-se em m\u00e9todos para apoiar a classifica\u00e7\u00e3o das subst\u00e2ncias medicamentosas e justificar a bioequival\u00eancia sem estudos <em>in vivo<\/em>, garantindo coer\u00eancia em termos de seguran\u00e7a e efic\u00e1cia.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_c42657-e1, .wp-block-kadence-advancedheading.kt-adv-heading223993_c42657-e1[data-kb-block=\"kb-adv-heading223993_c42657-e1\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_c42657-e1 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_c42657-e1[data-kb-block=\"kb-adv-heading223993_c42657-e1\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_c42657-e1 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_c42657-e1[data-kb-block=\"kb-adv-heading223993_c42657-e1\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_c42657-e1 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_c42657-e1\"><strong>\u00c2mbito do documento:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aplic\u00e1vel a <strong>formas farmac\u00eauticas s\u00f3lidas de liberta\u00e7\u00e3o imediata administradas por via oral ou suspens\u00f5es.<\/strong><\/li>\n\n\n\n<li>Relevante para altera\u00e7\u00f5es p\u00f3s-aprova\u00e7\u00e3o, pedidos de medicamentos gen\u00e9ricos e produtos utilizados durante o desenvolvimento cl\u00ednico.<\/li>\n\n\n\n<li>Exclui os produtos farmac\u00eauticos com um \u00edndice terap\u00eautico restrito e aqueles que requerem estudos cl\u00ednicos espec\u00edficos de bioequival\u00eancia.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-3 kt-pane223993_bb44c7-07\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\"><strong>Qualidade e equival\u00eancia para medicamentos e dispositivos m\u00e9dicos de uso t\u00f3pico<\/strong><\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\"><style>.wp-block-kadence-advancedheading.kt-adv-heading223993_6f989d-84, .wp-block-kadence-advancedheading.kt-adv-heading223993_6f989d-84[data-kb-block=\"kb-adv-heading223993_6f989d-84\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_6f989d-84 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_6f989d-84[data-kb-block=\"kb-adv-heading223993_6f989d-84\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_6f989d-84 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_6f989d-84[data-kb-block=\"kb-adv-heading223993_6f989d-84\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_6f989d-84 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_6f989d-84\"><strong>SUPAC-SS&nbsp; Qu\u00edmica, produ\u00e7\u00e3o e controlo: Teste de liberta\u00e7\u00e3o <em>in vitro<\/em> e bioequival\u00eancia <em>in vivo<\/em><\/strong><\/h3>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_49730b-0d, .wp-block-kadence-advancedheading.kt-adv-heading223993_49730b-0d[data-kb-block=\"kb-adv-heading223993_49730b-0d\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_49730b-0d mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_49730b-0d[data-kb-block=\"kb-adv-heading223993_49730b-0d\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_49730b-0d img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_49730b-0d[data-kb-block=\"kb-adv-heading223993_49730b-0d\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_49730b-0d wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_49730b-0d\"><strong>Resumo:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"http:\/\/www.fda.gov\/media\/71141\/download\" target=\"_blank\" data-type=\"link\" data-id=\"www.fda.gov\/media\/71141\/download\" rel=\"noreferrer noopener\">As diretrizes fornecem recomenda\u00e7\u00f5es<\/a> para os promotores farmac\u00eauticos sobre mudan\u00e7as na composi\u00e7\u00e3o dos componentes, no processo de produ\u00e7\u00e3o, na escala da produ\u00e7\u00e3o e no local de produ\u00e7\u00e3o para formas de farmac\u00eauticas semiss\u00f3lidas n\u00e3o est\u00e9reis.<\/li>\n\n\n\n<li>O documento visa garantir a qualidade cont\u00ednua do produto e as caracter\u00edsticas de desempenho para as <strong>formula\u00e7\u00f5es t\u00f3picas semiss\u00f3lidas, incluindo cremes, g\u00e9is, lo\u00e7\u00f5es e pomadas.<\/strong><\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_867ebc-a3, .wp-block-kadence-advancedheading.kt-adv-heading223993_867ebc-a3[data-kb-block=\"kb-adv-heading223993_867ebc-a3\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_867ebc-a3 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_867ebc-a3[data-kb-block=\"kb-adv-heading223993_867ebc-a3\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_867ebc-a3 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_867ebc-a3[data-kb-block=\"kb-adv-heading223993_867ebc-a3\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_867ebc-a3 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_867ebc-a3\"><strong>\u00c2mbito e aplica\u00e7\u00e3o:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>As diretrizes aplicam-se a novos pedidos de medicamentos (NDA), pedidos abreviados de novos medicamentos (ANDA) e pedidos abreviados de antibi\u00f3ticos (AADA) para formas farmac\u00eauticas semiss\u00f3lidas n\u00e3o est\u00e9reis.<\/li>\n\n\n\n<li><strong>Define os n\u00edveis de altera\u00e7\u00e3o,<\/strong> os testes qu\u00edmicos de controlo e de produ\u00e7\u00e3o recomendados, os testes de liberta\u00e7\u00e3o <em>in vitro<\/em> e os testes de bioequival\u00eancia <em>in vivo<\/em> para apoiar estas altera\u00e7\u00f5es.<\/li>\n\n\n\n<li>O documento especifica tamb\u00e9m as informa\u00e7\u00f5es de aplica\u00e7\u00e3o exigidas pelo <em>Center for Drug Evaluation and Research<\/em> (CDER) para manter a qualidade do produto.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_91c63d-86, .wp-block-kadence-advancedheading.kt-adv-heading223993_91c63d-86[data-kb-block=\"kb-adv-heading223993_91c63d-86\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_91c63d-86 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_91c63d-86[data-kb-block=\"kb-adv-heading223993_91c63d-86\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_91c63d-86 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_91c63d-86[data-kb-block=\"kb-adv-heading223993_91c63d-86\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_91c63d-86 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_91c63d-86\"><strong>Testes <\/strong><strong><em>in vitro<\/em><\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>O teste de liberta\u00e7\u00e3o <em>in vitro<\/em> envolve <strong>a compara\u00e7\u00e3o das taxas de liberta\u00e7\u00e3o do medicamento de diferentes lotes usando c\u00e9lulas de difus\u00e3o.<\/strong><\/li>\n\n\n\n<li>O teste \u00e9 realizado em duas fases, com intervalos de confian\u00e7a calculados para garantir que as taxas de libera\u00e7\u00e3o estejam dentro dos limites aceit\u00e1veis.<\/li>\n\n\n\n<li>Este m\u00e9todo ajuda a garantir a consist\u00eancia nas taxas de liberta\u00e7\u00e3o do medicamento ap\u00f3s altera\u00e7\u00f5es de produ\u00e7\u00e3o.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_4c35db-01, .wp-block-kadence-advancedheading.kt-adv-heading223993_4c35db-01[data-kb-block=\"kb-adv-heading223993_4c35db-01\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_4c35db-01 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_4c35db-01[data-kb-block=\"kb-adv-heading223993_4c35db-01\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_4c35db-01 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_4c35db-01[data-kb-block=\"kb-adv-heading223993_4c35db-01\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_4c35db-01 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_4c35db-01\"><strong>Testes <\/strong><strong><em>in vivo<\/em><\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Os estudos de bioequival\u00eancia <em>in vivo<\/em> visam <strong>documentar a bioequival\u00eancia do produto farmac\u00eautico<\/strong> em rela\u00e7\u00e3o ao medicamento de refer\u00eancia listado (RLD) ou ao produto fabricado antes da altera\u00e7\u00e3o.<\/li>\n\n\n\n<li>O desenho do estudo depende da atividade farmacol\u00f3gica do medicamento e da forma farmac\u00eautica, e o objetivo \u00e9 <strong>demonstrar que a exposi\u00e7\u00e3o sist\u00e9mica e o efeito terap\u00eautico permanecem inalterados<\/strong> apesar das altera\u00e7\u00f5es de produ\u00e7\u00e3o.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_1c0b4b-70, .wp-block-kadence-advancedheading.kt-adv-heading223993_1c0b4b-70[data-kb-block=\"kb-adv-heading223993_1c0b4b-70\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_1c0b4b-70 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_1c0b4b-70[data-kb-block=\"kb-adv-heading223993_1c0b4b-70\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_1c0b4b-70 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_1c0b4b-70[data-kb-block=\"kb-adv-heading223993_1c0b4b-70\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_1c0b4b-70 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_1c0b4b-70\"><strong>Produtos farmac\u00eauticos de uso t\u00f3pico &#8211; Diretriz EMA sobre qualidade e equival\u00eancia<\/strong><\/h3>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_f08aa1-b6, .wp-block-kadence-advancedheading.kt-adv-heading223993_f08aa1-b6[data-kb-block=\"kb-adv-heading223993_f08aa1-b6\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_f08aa1-b6 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_f08aa1-b6[data-kb-block=\"kb-adv-heading223993_f08aa1-b6\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_f08aa1-b6 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_f08aa1-b6[data-kb-block=\"kb-adv-heading223993_f08aa1-b6\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_f08aa1-b6 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_f08aa1-b6\"><strong>Resumo:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Este documento fornece diretrizes para a qualidade e a equival\u00eancia dos produtos medicinais t\u00f3picos, concentrando-se principalmente em m\u00e9todos <em>in vitro<\/em> para apoiar a equival\u00eancia terap\u00eautica.<\/li>\n\n\n\n<li>Sublinha a import\u00e2ncia de garantir a seguran\u00e7a, a efic\u00e1cia e a qualidade constante destes produtos atrav\u00e9s de rigorosos protocolos de teste e valida\u00e7\u00e3o.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_f0f493-40, .wp-block-kadence-advancedheading.kt-adv-heading223993_f0f493-40[data-kb-block=\"kb-adv-heading223993_f0f493-40\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_f0f493-40 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_f0f493-40[data-kb-block=\"kb-adv-heading223993_f0f493-40\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_f0f493-40 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_f0f493-40[data-kb-block=\"kb-adv-heading223993_f0f493-40\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_f0f493-40 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_f0f493-40\"><strong>\u00c2mbito do documento:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aplica-se aos produtos medicinais aplicados localmente e com a\u00e7\u00e3o local para uso cut\u00e2neo, mas \u00e9 tamb\u00e9m relevante para outras prepara\u00e7\u00f5es como produtos para uso auricular ou ocular. Exclui os produtos biol\u00f3gicos, os medicamentos \u00e0 base de plantas e os casos que requerem estudos cl\u00ednicos de equival\u00eancia terap\u00eautica.<\/li>\n\n\n\n<li>Fornece diretrizes espec\u00edficas sobre aspetos de qualidade n\u00e3o cobertos por outras diretrizes e define protocolos para os testes de equival\u00eancia sem a necessidade de estudos cl\u00ednicos de equival\u00eancia terap\u00eautica.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_e82ab7-2b, .wp-block-kadence-advancedheading.kt-adv-heading223993_e82ab7-2b[data-kb-block=\"kb-adv-heading223993_e82ab7-2b\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_e82ab7-2b mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_e82ab7-2b[data-kb-block=\"kb-adv-heading223993_e82ab7-2b\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_e82ab7-2b img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_e82ab7-2b[data-kb-block=\"kb-adv-heading223993_e82ab7-2b\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_e82ab7-2b wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_e82ab7-2b\"><strong>Caracter\u00edsticas dos estudos <em>in vitro<\/em> de permea\u00e7\u00e3o cut\u00e2nea<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u00c2mbito e fundamenta\u00e7\u00e3o: Estabelece perfis de permeabilidade caracter\u00edsticos utilizando testes discriminativos de permeabilidade in vitro (IVPT) para demonstrar a equival\u00eancia.<\/li>\n\n\n\n<li>Valida\u00e7\u00e3o do m\u00e9todo:\n<ul class=\"wp-block-list\">\n<li>Demonstra que as condi\u00e7\u00f5es dos IVPT s\u00e3o adequadas para a compara\u00e7\u00e3o dos produtos farmac\u00eauticos.<\/li>\n\n\n\n<li>Utiliza lotes com diferentes carater\u00edsticas de qualidade como controlos negativos para confirmar o poder discriminativo do teste.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_b03897-38, .wp-block-kadence-advancedheading.kt-adv-heading223993_b03897-38[data-kb-block=\"kb-adv-heading223993_b03897-38\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_b03897-38 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_b03897-38[data-kb-block=\"kb-adv-heading223993_b03897-38\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_b03897-38 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_b03897-38[data-kb-block=\"kb-adv-heading223993_b03897-38\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_b03897-38 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_b03897-38\"><strong>Produtos farmac\u00eauticos t\u00f3picos apresentados em ANDA: Estudos de teste de liberta\u00e7\u00e3o <em>in vitro<\/em> da FDA<\/strong><\/h3>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_077640-88, .wp-block-kadence-advancedheading.kt-adv-heading223993_077640-88[data-kb-block=\"kb-adv-heading223993_077640-88\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_077640-88 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_077640-88[data-kb-block=\"kb-adv-heading223993_077640-88\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_077640-88 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_077640-88[data-kb-block=\"kb-adv-heading223993_077640-88\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_077640-88 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_077640-88\"><strong>Resumo:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>O IVRT \u00e9 concebido para avaliar a taxa de liberta\u00e7\u00e3o dos ingredientes farmac\u00eauticos ativos a partir dos <a href=\"https:\/\/www.fda.gov\/media\/162476\/download\" data-type=\"link\" data-id=\"https:\/\/www.fda.gov\/media\/162476\/download\" target=\"_blank\" rel=\"noreferrer noopener\">produtos farmac\u00eauticos t\u00f3picos.<\/a><\/li>\n\n\n\n<li>Este m\u00e9todo desempenha um papel fundamental na demonstra\u00e7\u00e3o da bioequival\u00eancia entre medicamentos gen\u00e9ricos e medicamentos de refer\u00eancia, comparando os seus perfis de liberta\u00e7\u00e3o.<\/li>\n\n\n\n<li>O IVRT serve como uma ferramenta preditiva para avaliar o desempenho do produto, garantir a consist\u00eancia na produ\u00e7\u00e3o e apoiar as submiss\u00f5es regulamentares para os produtos t\u00f3picos.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_a13991-2f, .wp-block-kadence-advancedheading.kt-adv-heading223993_a13991-2f[data-kb-block=\"kb-adv-heading223993_a13991-2f\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_a13991-2f mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_a13991-2f[data-kb-block=\"kb-adv-heading223993_a13991-2f\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_a13991-2f img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_a13991-2f[data-kb-block=\"kb-adv-heading223993_a13991-2f\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_a13991-2f wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_a13991-2f\"><strong>\u00c2mbito do documento:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Uso nas submiss\u00f5es regulamentares para os pedidos abreviados de novos medicamentos (ANDA) para demonstrar a bioequival\u00eancia dos produtos farmac\u00eauticos t\u00f3picos.<\/li>\n\n\n\n<li>Aplic\u00e1vel a v\u00e1rias formula\u00e7\u00f5es semiss\u00f3lidos e l\u00edquidos &#8211; cremes, pomadas, g\u00e9is e lo\u00e7\u00f5es, que s\u00e3o aplicadas na pele ou nas superf\u00edcies mucosas.<\/li>\n\n\n\n<li>Essencial para os produtos para os quais os estudos de bioequival\u00eancia <em>in vivo<\/em> s\u00e3o dif\u00edceis ou impratic\u00e1veis.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_b05942-0e, .wp-block-kadence-advancedheading.kt-adv-heading223993_b05942-0e[data-kb-block=\"kb-adv-heading223993_b05942-0e\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_b05942-0e mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_b05942-0e[data-kb-block=\"kb-adv-heading223993_b05942-0e\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_b05942-0e img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_b05942-0e[data-kb-block=\"kb-adv-heading223993_b05942-0e\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_b05942-0e wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_b05942-0e\"><strong>Valida\u00e7\u00e3o do m\u00e9todo:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A valida\u00e7\u00e3o garante a fiabilidade atrav\u00e9s da qualifica\u00e7\u00e3o dos equipamentos e das membranas, da sele\u00e7\u00e3o de solu\u00e7\u00f5es recetoras apropriadas e da amostragem precisa. Inclui a manuten\u00e7\u00e3o de condi\u00e7\u00f5es ambientais controladas, a confirma\u00e7\u00e3o da liberta\u00e7\u00e3o linear do medicamento (r<sup>2<\/sup> \u2265 0,97) e a demonstra\u00e7\u00e3o de precis\u00e3o (%CV \u2264 15%) e reprodutibilidade.<\/li>\n\n\n\n<li>A capacidade de discrimina\u00e7\u00e3o \u00e9 verificada para diferenciar as formula\u00e7\u00f5es com taxas de liberta\u00e7\u00e3o vari\u00e1veis, apoiando a aceita\u00e7\u00e3o regulamentar e a bioequival\u00eancia dos produtos t\u00f3picos.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_dd355e-e5, .wp-block-kadence-advancedheading.kt-adv-heading223993_dd355e-e5[data-kb-block=\"kb-adv-heading223993_dd355e-e5\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_dd355e-e5 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_dd355e-e5[data-kb-block=\"kb-adv-heading223993_dd355e-e5\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_dd355e-e5 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_dd355e-e5[data-kb-block=\"kb-adv-heading223993_dd355e-e5\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_dd355e-e5 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_dd355e-e5\"><strong>Produtos farmac\u00eauticos t\u00f3picos apresentados em ANDA: Estudos de teste de permeabilidade <em>in vitro<\/em> da FDA<\/strong><\/h3>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_78b064-3a, .wp-block-kadence-advancedheading.kt-adv-heading223993_78b064-3a[data-kb-block=\"kb-adv-heading223993_78b064-3a\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_78b064-3a mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_78b064-3a[data-kb-block=\"kb-adv-heading223993_78b064-3a\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_78b064-3a img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_78b064-3a[data-kb-block=\"kb-adv-heading223993_78b064-3a\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_78b064-3a wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_78b064-3a\"><strong>Resumo:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Este documento fornece diretrizes para a condu\u00e7\u00e3o de testes de permeabilidade <em>in vitro<\/em> (IVPT) para apoiar a bioequival\u00eancia&nbsp; nos pedidos abreviados de novos medicamentos (ANDA) para <a href=\"https:\/\/www.fda.gov\/media\/162475\/download\" data-type=\"link\" data-id=\"https:\/\/www.fda.gov\/media\/162475\/download\" target=\"_blank\" rel=\"noreferrer noopener\">produtos farmac\u00eauticos t\u00f3picos<\/a>.<\/li>\n\n\n\n<li>Define o desenvolvimento, a valida\u00e7\u00e3o e a execu\u00e7\u00e3o dos estudos IVPT para garantir resultados precisos e reprodut\u00edveis para as submiss\u00f5es regulamentares.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_45626a-45, .wp-block-kadence-advancedheading.kt-adv-heading223993_45626a-45[data-kb-block=\"kb-adv-heading223993_45626a-45\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_45626a-45 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_45626a-45[data-kb-block=\"kb-adv-heading223993_45626a-45\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_45626a-45 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_45626a-45[data-kb-block=\"kb-adv-heading223993_45626a-45\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_45626a-45 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_45626a-45\"><strong>\u00c2mbito do documento:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aplic\u00e1vel aos produtos farmac\u00eauticos t\u00f3picos como pomadas, cremes, lo\u00e7\u00f5es, g\u00e9is e outras formula\u00e7\u00f5es \u00e0 base de semiss\u00f3lidos ou l\u00edquidos aplicados na pele.<\/li>\n\n\n\n<li>Projetado para ajudar os requerentes a demonstrar a bioequival\u00eancia entre um produto t\u00f3pico gen\u00e9rico e o seu padr\u00e3o de refer\u00eancia.<\/li>\n\n\n\n<li>Exclui os produtos farmac\u00eauticos administrados por via oft\u00e1lmica, \u00f3tica, nasal, inalat\u00f3ria, oral ou por inje\u00e7\u00e3o.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_f0a40e-81, .wp-block-kadence-advancedheading.kt-adv-heading223993_f0a40e-81[data-kb-block=\"kb-adv-heading223993_f0a40e-81\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_f0a40e-81 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_f0a40e-81[data-kb-block=\"kb-adv-heading223993_f0a40e-81\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_f0a40e-81 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_f0a40e-81[data-kb-block=\"kb-adv-heading223993_f0a40e-81\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_f0a40e-81 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_f0a40e-81\"><strong>Caracter\u00edsticas do M\u00e9todo IVPT:<\/strong><\/h3>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_9f8d58-d3, .wp-block-kadence-advancedheading.kt-adv-heading223993_9f8d58-d3[data-kb-block=\"kb-adv-heading223993_9f8d58-d3\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_9f8d58-d3 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_9f8d58-d3[data-kb-block=\"kb-adv-heading223993_9f8d58-d3\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_9f8d58-d3 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_9f8d58-d3[data-kb-block=\"kb-adv-heading223993_9f8d58-d3\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_9f8d58-d3 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_9f8d58-d3\"><strong>\u00c2mbito e aplica\u00e7\u00e3o:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>O m\u00e9todo IVPT foi concebido para avaliar a taxa de permea\u00e7\u00e3o do f\u00e1rmaco atrav\u00e9s da pele a partir de produtos farmac\u00eauticos t\u00f3picos. Este m\u00e9todo apoia os estudos de bioequival\u00eancia, fornecendo uma abordagem in vitro para avaliar o desempenho de um produto em teste em compara\u00e7\u00e3o com um padr\u00e3o de refer\u00eancia.<\/li>\n\n\n\n<li>Garante a efic\u00e1cia terap\u00eautica e a seguran\u00e7a consistente, avaliando as caracter\u00edsticas de liberta\u00e7\u00e3o e permeabilidade do medicamento, auxiliando nas decis\u00f5es regulat\u00f3rias relativas \u00e0 aprova\u00e7\u00e3o do produto e \u00e0s altera\u00e7\u00f5es p\u00f3s-aprova\u00e7\u00e3o.<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_dd46d5-80, .wp-block-kadence-advancedheading.kt-adv-heading223993_dd46d5-80[data-kb-block=\"kb-adv-heading223993_dd46d5-80\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_dd46d5-80 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_dd46d5-80[data-kb-block=\"kb-adv-heading223993_dd46d5-80\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_dd46d5-80 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_dd46d5-80[data-kb-block=\"kb-adv-heading223993_dd46d5-80\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_dd46d5-80 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_dd46d5-80\"><strong>Valida\u00e7\u00e3o do m\u00e9todo:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Qualifica\u00e7\u00e3o dos equipamentos.<\/li>\n\n\n\n<li>Qualifica\u00e7\u00e3o das membranas.<\/li>\n\n\n\n<li>Qualifica\u00e7\u00e3o das solu\u00e7\u00f5es recetoras.<\/li>\n\n\n\n<li>Qualifica\u00e7\u00e3o da amostragem.<\/li>\n\n\n\n<li>Precis\u00e3o e reprodutibilidade.<\/li>\n\n\n\n<li>Exaust\u00e3o da dose.<\/li>\n\n\n\n<li>Sensibilidade e especificidade de discrimina\u00e7\u00e3o.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-223993_928255-fe .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-223993_928255-fe .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-223993_928255-fe\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_c572f0-d4, .wp-block-kadence-advancedheading.kt-adv-heading223993_c572f0-d4[data-kb-block=\"kb-adv-heading223993_c572f0-d4\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_c572f0-d4 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_c572f0-d4[data-kb-block=\"kb-adv-heading223993_c572f0-d4\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_c572f0-d4 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_c572f0-d4[data-kb-block=\"kb-adv-heading223993_c572f0-d4\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading223993_c572f0-d4 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_c572f0-d4\">Os nossos servi\u00e7os<\/h2>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_077b72-7e, .wp-block-kadence-advancedheading.kt-adv-heading223993_077b72-7e[data-kb-block=\"kb-adv-heading223993_077b72-7e\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_077b72-7e mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_077b72-7e[data-kb-block=\"kb-adv-heading223993_077b72-7e\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_077b72-7e img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_077b72-7e[data-kb-block=\"kb-adv-heading223993_077b72-7e\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_077b72-7e wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_077b72-7e\"><strong>Estudos de absor\u00e7\u00e3o e efic\u00e1cia atrav\u00e9s de modelos <em>in vitro<\/em><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Os testes <em>in vitro<\/em> e os modelos apoiam todo o processo de produ\u00e7\u00e3o farmac\u00eautica, desde a ideia at\u00e9 \u00e0 comercializa\u00e7\u00e3o de um produto. Gra\u00e7as a diversas aplica\u00e7\u00f5es <em>in vitro<\/em>, \u00e9 poss\u00edvel simular os efeitos dos medicamentos atrav\u00e9s de <strong>modelos biol\u00f3gicos e estudos de absor\u00e7\u00e3o, executando v\u00e1rios testes de rastreio <\/strong>como:<\/p>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_53440c-62:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_53440c-62 ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_53440c-62 ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_53440c-62 ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items223993_53440c-62 ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items223993_53440c-62 kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-223993_4d7304-de .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_4d7304-de\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Identifica\u00e7\u00e3o do melhor princ\u00edpio ativo para um objetivo espec\u00edfico.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_ddaa4d-fa .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_ddaa4d-fa\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Otimiza\u00e7\u00e3o da f\u00f3rmula para melhorar a sua atividade biol\u00f3gica e propriedades.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_2398fc-85 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_2398fc-85\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Avalia\u00e7\u00e3o preliminar da bioacessibilidade\/biodisponibilidade.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_34bb2e-63 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_34bb2e-63\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Avalia\u00e7\u00e3o da efic\u00e1cia para avaliar preliminarmente o produto, o ingrediente ou a formula\u00e7\u00e3o antes de avan\u00e7ar para a avalia\u00e7\u00e3o seguinte (por exemplo, os ensaios cl\u00ednicos).<\/span><\/li>\n<\/ul><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Os nossos especialistas podem desenvolver v\u00e1rios modelos <em>in vitro<\/em> personalizados para diversas aplica\u00e7\u00f5es capazes de <strong>simular os efeitos dos medicamentos atrav\u00e9s de modelos biol\u00f3gicos e estudos de absor\u00e7\u00e3o<\/strong>, executando v\u00e1rios testes de triagem para avaliar preliminarmente o produto, o ingrediente ou a formula\u00e7\u00e3o antes de avan\u00e7ar para a avalia\u00e7\u00e3o seguinte (por exemplo, os ensaios cl\u00ednicos).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Os modelos biol\u00f3gicos s\u00e3o compostos por <strong>fluidos biol\u00f3gicos<\/strong> que representam o processo digestivo, o soro, o plasma, o tecido cerebral, o cora\u00e7\u00e3o e o sangue, a pr\u00f3stata e muitos outros. Os modelos s\u00e3o implement\u00e1veis e adapt\u00e1veis com base no tipo de fluido ou no estudo a ser realizado, e com base nas necessidades do cliente.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_e54d87-04, .wp-block-kadence-advancedheading.kt-adv-heading223993_e54d87-04[data-kb-block=\"kb-adv-heading223993_e54d87-04\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_e54d87-04 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_e54d87-04[data-kb-block=\"kb-adv-heading223993_e54d87-04\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_e54d87-04 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_e54d87-04[data-kb-block=\"kb-adv-heading223993_e54d87-04\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_e54d87-04 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_e54d87-04\"><strong>Protocolo de estudo de rastreio<\/strong><\/h4>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_543776-4c, .wp-block-kadence-advancedheading.kt-adv-heading223993_543776-4c[data-kb-block=\"kb-adv-heading223993_543776-4c\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_543776-4c mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_543776-4c[data-kb-block=\"kb-adv-heading223993_543776-4c\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_543776-4c img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_543776-4c[data-kb-block=\"kb-adv-heading223993_543776-4c\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h5 class=\"kt-adv-heading223993_543776-4c wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_543776-4c\"><strong>Teste de dissolu\u00e7\u00e3o:<\/strong><\/h5>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_569436-11:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_569436-11 ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_569436-11 ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_569436-11 ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items223993_569436-11 ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items223993_569436-11 kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-223993_b4eaba-78 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_b4eaba-78\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Teste de dissolu\u00e7\u00e3o padr\u00e3o de acordo com a EP\/USP.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_c939f8-75 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_c939f8-75\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Teste de dissolu\u00e7\u00e3o de liberta\u00e7\u00e3o lenta\/gradual de acordo com a EP\/USP.<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_60d62b-87, .wp-block-kadence-advancedheading.kt-adv-heading223993_60d62b-87[data-kb-block=\"kb-adv-heading223993_60d62b-87\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_60d62b-87 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_60d62b-87[data-kb-block=\"kb-adv-heading223993_60d62b-87\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_60d62b-87 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_60d62b-87[data-kb-block=\"kb-adv-heading223993_60d62b-87\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h5 class=\"kt-adv-heading223993_60d62b-87 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_60d62b-87\"><strong>An\u00e1lise <em>Shot-Gun<\/em> do teste de absor\u00e7\u00e3o:<\/strong><\/h5>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_716546-1a:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_716546-1a ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_716546-1a ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_716546-1a ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items223993_716546-1a ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items223993_716546-1a kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-223993_ac92ef-c9 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_ac92ef-c9\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Avalia\u00e7\u00e3o preliminar da biodisponibilidade &#8211; n\u00edvel sist\u00e9mico (para informa\u00e7\u00f5es de uso interno): estudo de absor\u00e7\u00e3o gastrointestinal utilizando um modelo <em>in vitro<\/em> de 2 fases.<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_037173-47, .wp-block-kadence-advancedheading.kt-adv-heading223993_037173-47[data-kb-block=\"kb-adv-heading223993_037173-47\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_037173-47 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_037173-47[data-kb-block=\"kb-adv-heading223993_037173-47\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_037173-47 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_037173-47[data-kb-block=\"kb-adv-heading223993_037173-47\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_037173-47 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_037173-47\"><strong>Protocolo de estudo completo<\/strong><\/h4>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_057ded-f0, .wp-block-kadence-advancedheading.kt-adv-heading223993_057ded-f0[data-kb-block=\"kb-adv-heading223993_057ded-f0\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_057ded-f0 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_057ded-f0[data-kb-block=\"kb-adv-heading223993_057ded-f0\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_057ded-f0 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_057ded-f0[data-kb-block=\"kb-adv-heading223993_057ded-f0\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h5 class=\"kt-adv-heading223993_057ded-f0 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_057ded-f0\"><strong>Estudo completo do teste de absor\u00e7\u00e3o:<\/strong><\/h5>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_53ae45-b8:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_53ae45-b8 ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_53ae45-b8 ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_53ae45-b8 ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items223993_53ae45-b8 ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items223993_53ae45-b8 kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-223993_0dbe70-70 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_0dbe70-70\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Avalia\u00e7\u00e3o da biodisponibilidade &#8211; n\u00edvel sist\u00e9mico (para uso regulamentar e\/ou divulga\u00e7\u00e3o cient\u00edfica): estudo de absor\u00e7\u00e3o gastrointestinal utilizando um modelo <em>in vitro<\/em> de 2 fases.<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_99e5fd-3d, .wp-block-kadence-advancedheading.kt-adv-heading223993_99e5fd-3d[data-kb-block=\"kb-adv-heading223993_99e5fd-3d\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_99e5fd-3d mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_99e5fd-3d[data-kb-block=\"kb-adv-heading223993_99e5fd-3d\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_99e5fd-3d img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_99e5fd-3d[data-kb-block=\"kb-adv-heading223993_99e5fd-3d\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h5 class=\"kt-adv-heading223993_99e5fd-3d wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_99e5fd-3d\"><strong>Estudo completo do teste de absor\u00e7\u00e3o com modelo avan\u00e7ado personalizado:<\/strong><\/h5>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_1458d1-48:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_1458d1-48 ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_1458d1-48 ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_1458d1-48 ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items223993_1458d1-48 ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items223993_1458d1-48 kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-223993_f62fa7-81 .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_f62fa7-81\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Avalia\u00e7\u00e3o da biodisponibilidade &#8211; n\u00edvel sist\u00e9mico (para uso regulamentar e\/ou divulga\u00e7\u00e3o cient\u00edfica): estudo de absor\u00e7\u00e3o gastrointestinal utilizando um modelo <em>in vitro<\/em> de 2 fases.<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_98f048-f8, .wp-block-kadence-advancedheading.kt-adv-heading223993_98f048-f8[data-kb-block=\"kb-adv-heading223993_98f048-f8\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_98f048-f8 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_98f048-f8[data-kb-block=\"kb-adv-heading223993_98f048-f8\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_98f048-f8 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_98f048-f8[data-kb-block=\"kb-adv-heading223993_98f048-f8\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h3 class=\"kt-adv-heading223993_98f048-f8 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_98f048-f8\"><strong>Bioequival\u00eancia<\/strong><\/h3>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_182bdd-3b, .wp-block-kadence-advancedheading.kt-adv-heading223993_182bdd-3b[data-kb-block=\"kb-adv-heading223993_182bdd-3b\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_182bdd-3b mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_182bdd-3b[data-kb-block=\"kb-adv-heading223993_182bdd-3b\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_182bdd-3b img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_182bdd-3b[data-kb-block=\"kb-adv-heading223993_182bdd-3b\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h4 class=\"kt-adv-heading223993_182bdd-3b wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_182bdd-3b\"><strong>System-based biowaivers<\/strong><\/h4>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_c53d59-b5, .wp-block-kadence-advancedheading.kt-adv-heading223993_c53d59-b5[data-kb-block=\"kb-adv-heading223993_c53d59-b5\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_c53d59-b5 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_c53d59-b5[data-kb-block=\"kb-adv-heading223993_c53d59-b5\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_c53d59-b5 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_c53d59-b5[data-kb-block=\"kb-adv-heading223993_c53d59-b5\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h5 class=\"kt-adv-heading223993_c53d59-b5 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_c53d59-b5\"><strong>Produtos farmac\u00eauticos de uso t\u00f3pico<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">Modelo <em>in vitro<\/em> de absor\u00e7\u00e3o efic\u00e1cia cut\u00e2nea. Para os testes pr\u00e9-cl\u00ednicos, s\u00e3o necess\u00e1rios modelos preditivos <em>in vitro<\/em> da pele humana para avaliar a efic\u00e1cia, a absor\u00e7\u00e3o e a seguran\u00e7a.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_1ea03e-8e, .wp-block-kadence-advancedheading.kt-adv-heading223993_1ea03e-8e[data-kb-block=\"kb-adv-heading223993_1ea03e-8e\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_1ea03e-8e mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_1ea03e-8e[data-kb-block=\"kb-adv-heading223993_1ea03e-8e\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_1ea03e-8e img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_1ea03e-8e[data-kb-block=\"kb-adv-heading223993_1ea03e-8e\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h5 class=\"kt-adv-heading223993_1ea03e-8e wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_1ea03e-8e\"><strong>Modelo de absor\u00e7\u00e3o atrav\u00e9s da barreira cut\u00e2nea<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fase de penetra\u00e7\u00e3o:<\/strong> difus\u00e3o passiva na camada c\u00f3rnea lipof\u00edlica;<\/li>\n\n\n\n<li><strong>Fase de permea\u00e7\u00e3o:<\/strong> o transporte atrav\u00e9s da epiderme viva mais aquosa e avascular at\u00e9 \u00e0 derme altamente perfundida;<\/li>\n\n\n\n<li><strong>Fase de reabsor\u00e7\u00e3o:<\/strong> na microcircula\u00e7\u00e3o e subsequentemente na circula\u00e7\u00e3o sist\u00e9mica ou mais profundamente no tecido (penetra\u00e7\u00e3o regional);<\/li>\n\n\n\n<li><strong>Afinidade do penetrante pela camada c\u00f3rnea ou pela derme<\/strong> (forma\u00e7\u00e3o de reserva).<\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-223993_5269f7-62 .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-223993_5269f7-62 .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-223993_5269f7-62\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_1292f6-f9, .wp-block-kadence-advancedheading.kt-adv-heading223993_1292f6-f9[data-kb-block=\"kb-adv-heading223993_1292f6-f9\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_1292f6-f9 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_1292f6-f9[data-kb-block=\"kb-adv-heading223993_1292f6-f9\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_1292f6-f9 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_1292f6-f9[data-kb-block=\"kb-adv-heading223993_1292f6-f9\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading223993_1292f6-f9 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_1292f6-f9\"><strong>As nossas publica\u00e7\u00f5es sobre estudos de absor\u00e7\u00e3o e efic\u00e1cia com modelos in vitro v\u00e1rios links<\/strong><\/h2>\n\n\n<style>.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_7d9b40-01:not(.this-stops-third-party-issues){margin-top:0px;margin-bottom:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_7d9b40-01 ul.kt-svg-icon-list:not(.this-prevents-issues):not(.this-stops-third-party-issues):not(.tijsloc){margin-top:0px;margin-right:0px;margin-bottom:var(--global-kb-spacing-sm, 1.5rem);margin-left:0px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_7d9b40-01 ul.kt-svg-icon-list{grid-row-gap:5px;}.wp-block-kadence-iconlist.kt-svg-icon-list-items223993_7d9b40-01 ul.kt-svg-icon-list .kt-svg-icon-list-item-wrap .kt-svg-icon-list-single{margin-right:10px;}.kt-svg-icon-list-items223993_7d9b40-01 ul.kt-svg-icon-list .kt-svg-icon-list-level-0 .kt-svg-icon-list-single svg{font-size:20px;}<\/style>\n<div class=\"wp-block-kadence-iconlist kt-svg-icon-list-items kt-svg-icon-list-items223993_7d9b40-01 kt-svg-icon-list-columns-1 alignnone kt-list-icon-aligntop\"><ul class=\"kt-svg-icon-list\"><style>.kt-svg-icon-list-item-223993_4791d5-7f .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_4791d5-7f\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><em>In vitro<\/em> behaviour of chitosan coated liposomes: \u201c<a href=\"https:\/\/www.walshmedicalmedia.com\/open-access\/analysis-of-operating-conditions-influencing-the-morphology-and-in-vitro-behaviour-of-chitosan-coated-liposomes-2157-7439.1000211.pdf\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/www.walshmedicalmedia.com\/open-access\/analysis-of-operating-conditions-influencing-the-morphology-and-in-vitro-behaviour-of-chitosan-coated-liposomes-2157-7439.1000211.pdf\" rel=\"noreferrer noopener\">Analysis of operating conditions influencing the morphology and <em>in vitro<\/em> behaviour of chitosan coated liposomes<\/a>\u201d J Nanomed Nanotechnol 5: 211.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_beb172-3c .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_beb172-3c\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><em>In vitro<\/em> toxicity assessment of oral nanocarriers: \u201c<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0169409X16302393?via%3Dihub\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0169409X16302393?via%3Dihub\" rel=\"noreferrer noopener\">In vitro toxicity assessment of oral nanocarriers<\/a>\u201d, Advanced Drug Delivery Reviews, Volume 106, Part B, 2016, Pages 381-401, ISSN 0169-409X.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_9d0e25-6e .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_9d0e25-6e\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Iron bioaccessibility, bioavailability, and intestinal absorption mechanisms: \u201c<a href=\"https:\/\/www.mdpi.com\/1420-3049\/25\/24\/5989\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/www.mdpi.com\/1420-3049\/25\/24\/5989\" rel=\"noreferrer noopener\">Comparative Evaluation of Intestinal Absorption and Functional Value of Iron Dietary Supplements and Drug with Different Delivery Systems<\/a>\u201d, Molecules, 25, 5989.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_501203-3f .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_501203-3f\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><em>In vitro<\/em> models that compare different commercial dietary supplements containing stabilized OSA to ascertain their bioaccessibility, bioavailability, and safety in a model of human intestinal epithelium: \u201c<a href=\"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/epdf\/10.1096\/fj.202000060RR\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/epdf\/10.1096\/fj.202000060RR\" rel=\"noreferrer noopener\">In vitro evaluation of different organic matrices used to modulate silicon bioavailability<\/a>\u201d, The FASEB Journal. 2020;34:12229\u201312238.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_8c9d13-bf .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_8c9d13-bf\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\">Digestive model through an integrated <em>in vitro<\/em> approach: \u201cComparative evaluation of intestinal absorption and functional value of iron dietary supplements and drug with different delivery systems\u201d, Molecules 2020, 25(24), 5989.<\/span><\/li>\n\n\n<style>.kt-svg-icon-list-item-223993_9ac96d-9d .kt-svg-icon-list-text mark.kt-highlight{background-color:unset;font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<li class=\"wp-block-kadence-listitem kt-svg-icon-list-item-wrap kt-svg-icon-list-item-223993_9ac96d-9d\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_checkCircle kt-svg-icon-list-single\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/><polyline points=\"22 4 12 14.01 9 11.01\"\/><\/svg><\/span><span class=\"kt-svg-icon-list-text\"><em>In vitro<\/em> efficacy testing to understand the mechanism of action: \u201cCapryloyl glycine and soy isoflavonoids in hypertrichosis: an experimental and placebo-controlled clinical study\u201d, DOI: 10.1111\/jocd.14096 -J Cosmet Dermatol. 2021;20(Suppl. 1):18\u201322.<\/span><\/li>\n<\/ul><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_d1b05c-62, .wp-block-kadence-advancedheading.kt-adv-heading223993_d1b05c-62[data-kb-block=\"kb-adv-heading223993_d1b05c-62\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_d1b05c-62 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_d1b05c-62[data-kb-block=\"kb-adv-heading223993_d1b05c-62\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_d1b05c-62 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_d1b05c-62[data-kb-block=\"kb-adv-heading223993_d1b05c-62\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading223993_d1b05c-62 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_d1b05c-62\"><strong>Os modelos in vitro<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A M\u00e9rieux NutriSciences pode apoiar todos os seus projetos com uma vasta gama de modelos <em>in vitro<\/em> implement\u00e1veis e adapt\u00e1veis com base no tipo de fluido ou estudo a ser realizado e de acordo com as necessidades do cliente.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Modelo de cora\u00e7\u00e3o e vasos sangu\u00edneos <em>in vitro<\/em><\/li>\n\n\n\n<li>Modelo oral <em>in vitro<\/em>: absor\u00e7\u00e3o oral e sublingual<\/li>\n\n\n\n<li>Modelo digestivo <em>in vitro<\/em>: bioacessibilidade<\/li>\n\n\n\n<li>Modelo de absor\u00e7\u00e3o intestinal <em>in vitro<\/em>: biodisponibilidade<\/li>\n\n\n\n<li>Modelo cut\u00e2neo <em>in vitro<\/em>: para estudos de absor\u00e7\u00e3o e efic\u00e1cia<\/li>\n\n\n\n<li>Modelo intestinal <em>in vitro<\/em><\/li>\n\n\n\n<li>Modelo hep\u00e1tico <em>in vitro<\/em><\/li>\n\n\n\n<li>Modelo cerebral <em>in vitro<\/em><\/li>\n\n\n\n<li>Modelo prost\u00e1tico <em>in vitro<\/em><\/li>\n<\/ul>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-223993_9df4f7-8a .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-223993_9df4f7-8a .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-223993_9df4f7-8a\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns223993_99c773-3f{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns223993_99c773-3f .kt-button{font-weight:normal;font-style:normal;}.kt-btns223993_99c773-3f .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns223993_99c773-3f .kt-btn-wrap-0 .kt-button{color:#555555;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns223993_99c773-3f .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns223993_99c773-3f .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns223993_99c773-3f .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns223993_99c773-3f .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns223993_99c773-3f .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns223993_99c773-3f\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn223993_bb49b6-2a.kb-button{width:initial;}<\/style><a class=\"kb-button kt-button button kb-btn223993_bb49b6-2a kt-btn-size-standard kt-btn-width-type-auto kb-btn-global-fill kt-btn-has-text-true kt-btn-has-svg-false wp-block-kadence-singlebtn\" href=\"https:\/\/www.merieuxnutrisciences.com\/pt\/contacto\/\"><span class=\"kt-btn-inner-text\">Fale connosco sobre os estudos de absor\u00e7\u00e3o para produtos farmac\u00eauticos<\/span><\/a><\/div>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-223993_9375a9-21 .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-223993_9375a9-21 .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-223993_9375a9-21\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading223993_299634-67, .wp-block-kadence-advancedheading.kt-adv-heading223993_299634-67[data-kb-block=\"kb-adv-heading223993_299634-67\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading223993_299634-67 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading223993_299634-67[data-kb-block=\"kb-adv-heading223993_299634-67\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading223993_299634-67 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading223993_299634-67[data-kb-block=\"kb-adv-heading223993_299634-67\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading223993_299634-67 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading223993_299634-67\">FAQ &#8211; Estudos de Absor\u00e7\u00e3o para Produtos Farmac\u00eauticos<\/h2>\n\n\n<style>.kt-accordion-id223993_779e0c-9f .kt-accordion-inner-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:0px;}.kt-accordion-id223993_779e0c-9f .kt-accordion-panel-inner{border-top:0px solid transparent;border-right:0px solid transparent;border-bottom:0px solid transparent;border-left:0px solid transparent;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-right:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);padding-left:var(--global-kb-spacing-sm, 1.5rem);}.kt-accordion-id223993_779e0c-9f > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header{border-top:1px solid #f2f2f2;border-right:1px solid #f2f2f2;border-bottom:1px solid #f2f2f2;border-left:1px solid #f2f2f2;border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;background:#f2f2f2;color:#555555;padding-top:9px;padding-right:13px;padding-bottom:9px;padding-left:13px;}.kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle )  > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle )  > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap .kt-blocks-accordion-icon-trigger:before{background:#555555;}.kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-icon-trigger{background:#555555;}.kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-icon-trigger:before{background:#f2f2f2;}.kt-accordion-id223993_779e0c-9f > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header:hover, \n\t\t\t\tbody:not(.hide-focus-outline) .kt-accordion-id223993_779e0c-9f .kt-blocks-accordion-header:focus-visible{color:#444444;background:#eeeeee;border-top:1px solid #878787;border-right:1px solid #878787;border-bottom:1px solid #878787;border-left:1px solid #878787;}.kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle ) .kt-accordion-header-wrap .kt-blocks-accordion-header:hover .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle ) .kt-accordion-header-wrap .kt-blocks-accordion-header:hover .kt-blocks-accordion-icon-trigger:before, body:not(.hide-focus-outline) .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle ) .kt-blocks-accordion--visible .kt-blocks-accordion-icon-trigger:after, body:not(.hide-focus-outline) .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle ) .kt-blocks-accordion-header:focus-visible .kt-blocks-accordion-icon-trigger:before{background:#444444;}.kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:hover .kt-blocks-accordion-icon-trigger, body:not(.hide-focus-outline) .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible .kt-blocks-accordion-icon-trigger{background:#444444;}.kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:hover .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:hover .kt-blocks-accordion-icon-trigger:before, body:not(.hide-focus-outline) .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible .kt-blocks-accordion-icon-trigger:after, body:not(.hide-focus-outline) .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible .kt-blocks-accordion-icon-trigger:before{background:#eeeeee;}.kt-accordion-id223993_779e0c-9f .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible,\n\t\t\t\t.kt-accordion-id223993_779e0c-9f > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header.kt-accordion-panel-active{color:#ffffff;background:#444444;border-top:1px solid #444444;border-right:1px solid #444444;border-bottom:1px solid #444444;border-left:1px solid #444444;}.kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle )  > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basiccircle ):not( .kt-accodion-icon-style-xclosecircle ):not( .kt-accodion-icon-style-arrowcircle )  > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger:before{background:#ffffff;}.kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger{background:#ffffff;}.kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger:after, .kt-accordion-id223993_779e0c-9f:not( .kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger:before{background:#444444;}@media all and (max-width: 1024px){.kt-accordion-id223993_779e0c-9f .kt-accordion-panel-inner{border-top:0px solid transparent;border-right:0px solid transparent;border-bottom:0px solid transparent;border-left:0px solid transparent;}}@media all and (max-width: 1024px){.kt-accordion-id223993_779e0c-9f > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header{border-top:1px solid #f2f2f2;border-right:1px solid #f2f2f2;border-bottom:1px solid #f2f2f2;border-left:1px solid #f2f2f2;}}@media all and (max-width: 1024px){.kt-accordion-id223993_779e0c-9f > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header:hover, \n\t\t\t\tbody:not(.hide-focus-outline) .kt-accordion-id223993_779e0c-9f .kt-blocks-accordion-header:focus-visible{border-top:1px solid #878787;border-right:1px solid #878787;border-bottom:1px solid #878787;border-left:1px solid #878787;}}@media all and (max-width: 1024px){.kt-accordion-id223993_779e0c-9f .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible,\n\t\t\t\t.kt-accordion-id223993_779e0c-9f > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header.kt-accordion-panel-active{border-top:1px solid #444444;border-right:1px solid #444444;border-bottom:1px solid #444444;border-left:1px solid #444444;}}@media all and (max-width: 767px){.kt-accordion-id223993_779e0c-9f .kt-accordion-inner-wrap{display:block;}.kt-accordion-id223993_779e0c-9f .kt-accordion-inner-wrap .kt-accordion-pane:not(:first-child){margin-top:0px;}.kt-accordion-id223993_779e0c-9f .kt-accordion-panel-inner{border-top:0px solid transparent;border-right:0px solid transparent;border-bottom:0px solid transparent;border-left:0px solid transparent;}.kt-accordion-id223993_779e0c-9f > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header{border-top:1px solid #f2f2f2;border-right:1px solid #f2f2f2;border-bottom:1px solid #f2f2f2;border-left:1px solid #f2f2f2;}.kt-accordion-id223993_779e0c-9f > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header:hover, \n\t\t\t\tbody:not(.hide-focus-outline) .kt-accordion-id223993_779e0c-9f .kt-blocks-accordion-header:focus-visible{border-top:1px solid #878787;border-right:1px solid #878787;border-bottom:1px solid #878787;border-left:1px solid #878787;}.kt-accordion-id223993_779e0c-9f .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible,\n\t\t\t\t.kt-accordion-id223993_779e0c-9f > .kt-accordion-inner-wrap > .wp-block-kadence-pane > .kt-accordion-header-wrap > .kt-blocks-accordion-header.kt-accordion-panel-active{border-top:1px solid #444444;border-right:1px solid #444444;border-bottom:1px solid #444444;border-left:1px solid #444444;}}<\/style>\n<div class=\"wp-block-kadence-accordion alignnone\"><div class=\"kt-accordion-wrap kt-accordion-id223993_779e0c-9f kt-accordion-has-10-panes kt-active-pane-0 kt-accordion-block kt-pane-header-alignment-left kt-accodion-icon-style-basic kt-accodion-icon-side-right\" style=\"max-width:none\"><div class=\"kt-accordion-inner-wrap\" data-allow-multiple-open=\"false\" data-start-open=\"none\">\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-1 kt-pane223993_f1edc3-fd\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">O que significa \u201cestudo de absor\u00e7\u00e3o in vitro\u201d e porque \u00e9 importante na ind\u00fastria farmac\u00eautica?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p class=\"wp-block-paragraph\">Um estudo de absor\u00e7\u00e3o in vitro \u00e9 uma simula\u00e7\u00e3o laboratorial do processo de absor\u00e7\u00e3o de um medicamento no organismo humano.<br>Estes testes permitem compreender como um princ\u00edpio ativo \u00e9 libertado, dissolvido e absorvido a n\u00edvel intestinal, cut\u00e2neo ou em outros tecidos, sem recorrer a ensaios em humanos.<br>S\u00e3o fundamentais para avaliar a <strong>efic\u00e1cia, seguran\u00e7a e biodisponibilidade<\/strong> de medicamentos e suplementos antes da fase cl\u00ednica.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-2 kt-pane223993_ff4c07-3c\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Que tipo de produtos podem ser avaliados atrav\u00e9s de estudos de absor\u00e7\u00e3o in vitro?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p class=\"wp-block-paragraph\">Podem ser avaliados <strong>medicamentos, dispositivos m\u00e9dicos, cosm\u00e9ticos e suplementos alimentares<\/strong>.<br>Os testes s\u00e3o especialmente \u00fateis em <strong>formula\u00e7\u00f5es t\u00f3picas, orais, digestivas e transd\u00e9rmicas<\/strong>, onde \u00e9 essencial prever a absor\u00e7\u00e3o e efic\u00e1cia sem comprometer a seguran\u00e7a.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-3 kt-pane223993_111dc1-15\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Que modelos biol\u00f3gicos utiliza a M\u00e9rieux NutriSciences?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p class=\"wp-block-paragraph\">Utilizamos <strong>modelos biol\u00f3gicos avan\u00e7ados<\/strong> que replicam diferentes partes do corpo humano:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Modelo digestivo e intestinal<\/strong>, para estudar biodisponibilidade e bioacessibilidade;<\/li>\n\n\n\n<li><strong>Modelo cut\u00e2neo<\/strong>, para avaliar absor\u00e7\u00e3o e efic\u00e1cia de produtos t\u00f3picos;<\/li>\n\n\n\n<li><strong>Modelos hep\u00e1tico, cerebral e prost\u00e1tico<\/strong>, para investiga\u00e7\u00f5es espec\u00edficas de tecidos;<\/li>\n\n\n\n<li><strong>Modelos cardiovasculares e de plasma<\/strong>, para compreender a difus\u00e3o sist\u00e9mica.<br>Estes modelos s\u00e3o adapt\u00e1veis \u00e0s necessidades de cada cliente e regulamento.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-4 kt-pane223993_6faa8b-bf\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Qual \u00e9 a diferen\u00e7a entre biodisponibilidade e bioequival\u00eancia?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p class=\"wp-block-paragraph\"><strong>Biodisponibilidade<\/strong> refere-se \u00e0 <strong>quantidade e velocidade<\/strong> com que o princ\u00edpio ativo de um medicamento entra na corrente sangu\u00ednea e se torna dispon\u00edvel para atuar.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bioequival\u00eancia<\/strong> compara duas formula\u00e7\u00f5es diferentes do mesmo f\u00e1rmaco, garantindo que ambas t\u00eam o mesmo efeito terap\u00eautico.<br>Os estudos in vitro ajudam a demonstrar ambas, muitas vezes dispensando ensaios cl\u00ednicos completos (<em>biowaivers<\/em>).<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-5 kt-pane223993_c19fbc-2a\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">O que \u00e9 um biowaiver e qual o seu papel na regulamenta\u00e7\u00e3o farmac\u00eautica?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p class=\"wp-block-paragraph\">Um <strong>biowaiver<\/strong> (bioisen\u00e7\u00e3o) \u00e9 a <strong>dispensa de ensaios cl\u00ednicos de bioequival\u00eancia<\/strong>, quando estudos in vitro demonstram que duas formula\u00e7\u00f5es s\u00e3o equivalentes.<br>\u00c9 um procedimento reconhecido por entidades como a <strong>EMA<\/strong> e a <strong>FDA<\/strong>, permitindo reduzir custos e tempo de aprova\u00e7\u00e3o de medicamentos gen\u00e9ricos ou reformulados.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-6 kt-pane223993_81edbc-c6\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Quais s\u00e3o as principais acredita\u00e7\u00f5es do ECSIN LAB?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p class=\"wp-block-paragraph\">O ECSIN LAB \u00e9 <strong>acreditado para an\u00e1lises de micropl\u00e1sticos, nanomateriais e estudos de absor\u00e7\u00e3o in vitro<\/strong>, conforme as normas <strong>EP\/USP<\/strong> e <strong>ISO 17025<\/strong>.<br>Foi o <strong>primeiro laborat\u00f3rio acreditado<\/strong> para an\u00e1lises de micropl\u00e1sticos em alimentos, ra\u00e7\u00f5es e \u00e1guas, refor\u00e7ando a sua posi\u00e7\u00e3o como parceiro de confian\u00e7a na investiga\u00e7\u00e3o farmac\u00eautica.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-7 kt-pane223993_753690-69\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Como a M\u00e9rieux NutriSciences garante a fiabilidade dos seus estudos de absor\u00e7\u00e3o?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p class=\"wp-block-paragraph\">A fiabilidade \u00e9 assegurada atrav\u00e9s de:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Protocolos normalizados (EP\/USP)<\/strong>;<\/li>\n\n\n\n<li><strong>Equipas cient\u00edficas altamente qualificadas<\/strong>;<\/li>\n\n\n\n<li><strong>Controlo de qualidade e valida\u00e7\u00e3o interna<\/strong>;<\/li>\n\n\n\n<li><strong>Revis\u00e3o cient\u00edfica e conformidade regulamentar<\/strong>.<br>Cada estudo \u00e9 documentado para garantir rastreabilidade e conformidade com os padr\u00f5es internacionais.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-8 kt-pane223993_5fa2db-74\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Os estudos de absor\u00e7\u00e3o podem ser personalizados?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p class=\"wp-block-paragraph\">Sim. A M\u00e9rieux NutriSciences desenvolve <strong>projetos personalizados<\/strong> com base nas caracter\u00edsticas do produto e nos objetivos do estudo.<br>Podem ser ajustados par\u00e2metros como tipo de fluido biol\u00f3gico, dura\u00e7\u00e3o do ensaio, temperatura, pH e modelo celular utilizado.<br>Esta flexibilidade garante resultados cient\u00edficos relevantes e aplic\u00e1veis a contextos reais.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-9 kt-pane223993_365ac7-ae\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Como posso solicitar um estudo de absor\u00e7\u00e3o in vitro \u00e0 M\u00e9rieux NutriSciences?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p class=\"wp-block-paragraph\">Pode entrar em contacto com a equipa atrav\u00e9s do formul\u00e1rio dispon\u00edvel na p\u00e1gina ou diretamente pelo <strong>departamento farmac\u00eautico da M\u00e9rieux NutriSciences Portugal<\/strong>.<br>Ap\u00f3s uma an\u00e1lise inicial, os especialistas definem o <strong>modelo experimental mais adequado<\/strong> e apresentam uma proposta personalizada com base nas necessidades do cliente.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-10 kt-pane223993_170e3d-0a\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Em que se diferencia o ECSIN LAB de outros laborat\u00f3rios farmac\u00eauticos?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p class=\"wp-block-paragraph\">O ECSIN LAB distingue-se por:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fazer parte da <strong>rede global M\u00e9rieux NutriSciences<\/strong>;<\/li>\n\n\n\n<li>Combinar <strong>inova\u00e7\u00e3o cient\u00edfica e aplica\u00e7\u00e3o regulat\u00f3ria<\/strong>;<\/li>\n\n\n\n<li>Possuir <strong>modelos in vitro exclusivos e acreditados<\/strong>;<\/li>\n\n\n\n<li>Participar em <strong>projetos de investiga\u00e7\u00e3o europeus<\/strong> que moldam o futuro dos ensaios farmac\u00eauticos.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<div class=\"page-cards-block-wrapper fullwidth-block\">   \n    <div class=\"page-cards-title-container\"> \n        <h2>Servi\u00e7os relacionados<\/h2>    \n    <\/div>\n    <div class=\"full-width-row-page-cards-wrapper\">\n        <div class=\"page-cards-container\">\n                                            <a href=\"https:\/\/www.merieuxnutrisciences.com\/pt\/produtos-farmaceuticos-e-dispositivos-medicos\/produtos-farmaceuticos\/\" class=\"card\">\n                                            <img decoding=\"async\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/medicine1.svg\" alt=\"Produtos farmac\u00eauticos\" class=\"card-icon\"\/>\n                                        <div class=\"card-content\">\n                        <span>Produtos farmac\u00eauticos<\/span>\n                    <\/div>\n                <\/a>\n                                <\/div>\n    <\/div>\n<\/div>    \n   \n\n<style>\n.fullwidth-block {\n    max-width: none !important;\n    width: 100vw !important;\n    position: relative;\n    padding:0px;\n    \/* left: 50%;\n    right: 50%;\n    margin-left: -50vw;\n    margin-right: -50vw; *\/\n}\n\n.page-cards-title-container{\n    max-width: 1290px;\n    margin: 100px auto 150px auto;\n    padding-left: var(--global-content-edge-padding);\n    padding-right: var(--global-content-edge-padding);\n}\n.page-cards-title-container h2{\n    color:var(--global-palette4);\n    text-align: center;\n}\n.full-width-row-page-cards-wrapper{\n    background-color: var(--global-palette4);\n}\n.page-cards-container{\n    max-width:1290px;\n    margin: 0 auto;\n    display: flex;\n    gap: 20px;\n    align-items: center;\n    justify-content: center;\n    padding: 0 12px;\n    flex-wrap: wrap;\n}\n.card {\n    display: flex;\n    transform: translate(0px, -100px);\n    flex-direction: column;\n    align-items: center;\n    justify-content: center;\n    width: 200px;\n    height: 200px;\n    background-color: white;\n    text-decoration: none;\n    color: black;\n    border: 1px solid #ccc;\n    padding: 10px;\n    box-shadow: 0 2px 5px rgba(0,0,0,0.1);\n    border-radius: 8px;\n    overflow: hidden;\n}\n\n.card-icon {\n    align-self: center;\n    width: 80px; \n    height: auto;\n    margin-bottom: 10px;\n}\n.card-content{\n    display:flex;\n    justify-content: center;\n}\n\n.card-content span{\n    color:var(--global-palette3);\n    text-align: center;\n    text-transform: uppercase;\n    margin: 5px 0;\n    line-height: 1.2em;\n    font-size: 16px;\n    font-weight:bold;\n}\n\n.card:hover {\n    animation: all ease-in-out 0.3s;\n    transform: scale(.95) translate(0px, -100px);\n    box-shadow: 0 4px 8px rgba(0,0,0,0.2);\n}\n\n@media (max-width: 767px) {\n    .page-cards-container {\n        flex-direction: column;\n        align-items: center;\n    }\n    .page-cards-title-container{\n        text-align: center;\n    }\n    \n}\n\n@media (min-width: 768px) and (max-width: 1023px) {\n    .page-cards-container {\n        flex-wrap: wrap;\n        justify-content: space-around;\n    }\n    .page-cards-title-container{\n        text-align: center;\n    }\n\n}\n\n<\/style>\n","protected":false},"excerpt":{"rendered":"<p>O ECSIN LAB, com sede em It\u00e1lia e parte do grupo M\u00e9rieux NutriSciences, \u00e9 um laborat\u00f3rio de inova\u00e7\u00e3o que une o foco na efic\u00e1cia das solu\u00e7\u00f5es propostas com a participa\u00e7\u00e3o em projetos cient\u00edficos estrat\u00e9gicos internacionais para o futuro. O nosso laborat\u00f3rio Informa\u00e7\u00f5es principais Capacidade Acredita\u00e7\u00f5es Refer\u00eancias regulamentares Os nossos servi\u00e7os Estudos de absor\u00e7\u00e3o e efic\u00e1cia&#8230;<\/p>\n","protected":false},"author":16,"featured_media":113131,"parent":18531,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"service-page-pharma-blue.php","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"folder":[1758],"class_list":["post-223993","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"taxonomy_info":[],"featured_image_src_large":["https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2024\/09\/shutterstock_744413632_Extractables-and-leachables.jpg",1024,576,false],"author_info":{"display_name":"Rui Nogueira","author_link":"https:\/\/www.merieuxnutrisciences.com\/pt\/author\/rui\/"},"comment_info":0,"_links":{"self":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/pages\/223993","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/comments?post=223993"}],"version-history":[{"count":35,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/pages\/223993\/revisions"}],"predecessor-version":[{"id":225034,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/pages\/223993\/revisions\/225034"}],"up":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/pages\/18531"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/media\/113131"}],"wp:attachment":[{"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/media?parent=223993"}],"wp:term":[{"taxonomy":"folder","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/pt\/wp-json\/wp\/v2\/folder?post=223993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}