In vitro toxicity tests are an important tool in evaluating the safety and tolerability of cosmetics and personal care products. Mérieux NutriSciences offers proven practical experience in the application of GLP-compliant, validated* biochemical and in vitro toxicology testing methods.

We combine different in vitro methods as part of an integrated testing strategy (ITS) for safety evaluation. This enables us to get closer to the overall goal of predictive in vitro risk evaluation processes to eliminate or reduce the use of animal testing.

 

Mérieux NutriSciences offers a wide range of ITS in vitro validated assays using cell models and 3D human reconstructed tissues for the evaluation of:

  • Skin irritation and corrosion
  • Eye irritation
  • Skin sensitization
  • Phototoxicity
  • Cytotoxicity
  • Mutagenicity

 

SKIN IRRITATION
In vitro skin irritation                                OECD 439 | RHE

EYE IRRITATION
Eye irritation EpiOcular™ EIT test          OECD 492 | RhCE
Eye irritation STE test                               OECD 491 |  Cell line

SKIN CORROSION 
In vitro skin corrosion                               OECD 431 | RHE

PHOTOTOXICITY TEST
Phototoxicity test 3T3 NRU                      OECD 432 | Cell line

SKIN SENSITISATION
epiCS®                                                                           RHE
Human-cell line activation (hCLAT)         OECD draft | Cell line
Direct Peptide Reactivity Essay (DPRA)  OECD 442C | Synthetic peptides
KeratinoSenseTM                                      OECD 442D (with partner) | Cell line

GENOTOXICITY
Ames test                                                  OECD 471 | Bacterial strains
MLA                                                           OECD 490 | Cell line
Micronucleus test                                     OECD 487 | Cell line

 

*Or for which validation is currently in progress

October 11th, 2021
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