December 2nd, 2021
Scientific writing: In vitro efficacy testing to understand the mechanism of action
Mérieux NutriSciences - In Vitro Efficacy Testing


In March, together with the Department of Pathophysiology and Transplantation’ researchers -University of Milan-, ECSIN LAB published a new article entitled Capryloyl glycine and soy isoflavonoids in hypertrichosis: an experimental and placebo-controlled clinical study, on Journal of Cosmetic Dermatology.

In vitro efficacy testing to understand the mechanism of action of a product
In vitro models mimicking different biological activities can be adopted to evaluate the efficacy of products, ingredients or new formulation and understand the mechanism of action.

The aim of the study
The study evaluates a cream for hair removal, for those suffering from hypertrichosis (HT). HT is an abnormal increase of hair on skin surface –regardless of race, gender, age, or skin area– as there is still no definitive cure and clinical results are often unsatisfactory, effective hair removal is important for those prone to this disease.
The aim of the study was to evaluate the potential inhibition of Ornithine decarboxylase 1 (ODC1) activity by a cream containing 4% capryloyl glycine (ODC1 inhibitor) and 1% glycine soy-fermented extract (soy isoflavonoids). ODC1 is an enzyme present in hair follicles that is considered as a potential target to inhibit hair growth. In parallel, a placebo-controlled clinical trial was conducted to evaluate the efficacy and tolerability of the treatment in patients.

The cream showed to be effective in patients with hypertrichosis located on the forearms.
In vitro enzymatic efficacy test
The tested cream significantly inhibited ODC1 activity (35.1 ± 0.5% reduction, equivalent to 64.9 ± 0.5% ODC1 activity).
Clinical study on patients
In 91.7% of patients treated with the product containing the active ingredients, an improvement of disease conditions was observed. On the contrary, no improvement was observed in patients treated with a placebo cream.

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