{"id":194621,"date":"2025-07-01T08:57:54","date_gmt":"2025-07-01T07:57:54","guid":{"rendered":"https:\/\/www.merieuxnutrisciences.com\/servicios-farmaceuticos\/absorption-studies\/"},"modified":"2025-12-22T12:01:59","modified_gmt":"2025-12-22T12:01:59","slug":"estudios-absorcion","status":"publish","type":"page","link":"https:\/\/www.merieuxnutrisciences.com\/es\/servicios-farmaceuticos\/estudios-absorcion\/","title":{"rendered":"Estudios de Absorci\u00f3n en Productos Farmac\u00e9uticos"},"content":{"rendered":"\n<div class=\"page-header-block-wrapper fullwidth-block\">\n    <div class=\"acf-page-header\" style=\"background-image: url('https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2024\/09\/shutterstock_744413632_Extractables-and-leachables.jpg'); \">\n        <div class=\"overlay\"><\/div>\n        <div class=\"acf-page-header-container\">\n                            <div class=\"image-wrapper\">\n                    <img decoding=\"async\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/studi-assorbiento.png\" alt=\"Icon\" \/>\n                <\/div>\n                        <h1>Estudios de Absorci\u00f3n en Productos Farmac\u00e9uticos<\/h1>\n        <\/div>\n    <\/div>\n<\/div>\n\n<style>\n.page-header-block-wrapper{\n    margin-bottom: 60px;\n}\n\n.fullwidth-block {\n    max-width: none !important;\n    width: 100vw !important;\n    position: relative;\n    padding:0px;\n    left: 50%;\n    right: 50%;\n    margin-left: -50vw;\n    margin-right: -50vw;\n}\n\n.acf-page-header {\n    background-size: cover;\n    background-position: center;\n    display: flex;\n    position: relative;\n    min-height: 250px; \n}\n\n.acf-page-header-container{\n    margin: 0 auto;\n    padding: 48px 24px;\n    display: flex;\n    flex-direction: column;\n    justify-content: end;\n    align-items: center;\n}\n\n.acf-page-header .overlay {\n    position: absolute;\n    top: 0;\n    left: 0;\n    right: 0;\n    bottom: 0;\n    background: linear-gradient(to top, var(--global-palette4), transparent);\n    z-index: 1;\n}\n\n.acf-page-header-container .image-wrapper{\n    position:relative;\n    height: 70px;\n    width: 70px;\n    background: var(--global-palette4);\n    border-radius: 50%;\n    z-index: 1;\n}\n\n.acf-page-header-container img{\n    position: absolute;\n    top: 50%;\n    left: 50%;\n    transform: translate(-50%, -50%);\n    max-width:40px;\n    z-index: 2;\n}\n\n.acf-page-header h1 {\n    display:block;\n    position: relative;\n    z-index: 2;\n    color:white;\n    text-align: center;\n}\n\n@media (min-width: 1025px) {\n    .acf-page-header-container{\n        width: 1290px;\n    }\n    \n}\n\n@media (max-width: 1024px) {\n    .acf-page-header-container {\n        align-self: end;\n    }\n    .acf-page-header .overlay {\n        background: linear-gradient(to top, var(--global-palette4), transparent);\n    }\n}\n\n@media (max-width: 768px) {\n    .acf-page-header .overlay {\n        background: linear-gradient(to top, var(--global-palette4), transparent);\n    }\n    .acf-page-header h1 {\n        font-size:28px;\n    }\n}\n\n<\/style>\n\n\n\n\n<p>Ubicado en Italia, <strong>ECSIN LAB<\/strong> \u2013 parte del grupo <strong>M\u00e9rieux NutriSciences<\/strong> \u2013 es un laboratorio de innovaci\u00f3n que combina el enfoque hacia la eficacia de las soluciones propuestas con la participaci\u00f3n en proyectos cient\u00edficos estrat\u00e9gicos internacionales innovadores.<span id=\"docs-internal-guid-4cd47c25-7fff-d93d-f773-637b4a0aa0a5\"><\/span><\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Estudios de Absorci\u00f3n: Nuestro Laboratorio<\/strong><\/h2>\n\n\n        <div class=\"wp-block-accordion\">\n            \n                                    <div class=\"nq-c-Dropdown\" data-nqis=\"Dropdown\">\n                        <div data-nqdisplay=\"small\"><\/div>\n                        <div data-nqdisplay=\"large\"><\/div>\n    \n                        <div class=\"nq-c-Dropdown-toggler nq-c-Heading nq-u-blue\" data-lvl=\"3\" aria-expanded=\"false\">\n                            <span class=\"nq-c-Dropdown-toggler-txt\">Datos claves<\/span>\n                            <span class=\"nq-c-Dropdown-toggler-icon\">\n                                \n                                <span class=\"icon-minus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20.000000pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M936 2697 c-109 -61 -106 -221 5 -277 38 -20 66 -20 1619 -20 1553 0\n1581 0 1619 20 113 57 113 223 0 280 -38 20 -66 20 -1621 20 l-1583 0 -39 -23z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                <span class=\"icon-plus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M2480 4288 c-18 -13 -43 -36 -54 -51 -21 -28 -21 -35 -24 -773 l-2\n-744 -744 -2 c-738 -3 -745 -3 -773 -24 -98 -73 -98 -195 0 -268 28 -21 35\n-21 773 -24 l744 -2 2 -744 c3 -738 3 -745 24 -773 73 -98 195 -98 268 0 21\n28 21 35 24 773 l2 744 744 2 c738 3 745 3 773 24 98 73 98 195 0 268 -28 21\n-35 21 -773 24 l-744 2 -2 744 c-3 738 -3 745 -24 773 -35 48 -82 73 -134 73\n-32 0 -57 -7 -80 -22z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                \n                            <\/span>\n                        <\/div>\n                        <div class=\"nq-c-Dropdown-menu\" hidden>\n                                                            <ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Equipo de investigadores altamente cualificados,<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Participaci\u00f3n en grupos de trabajo nacionales e internacionales,<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Participaci\u00f3n en proyectos estrat\u00e9gicos a nivel nacional e internacional,<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Publicaciones cient\u00edficas.<\/span><\/li>\n<\/ul>\n    \n                                                                                    <\/div>\n                    <\/div>\n                            \n                                    <div class=\"nq-c-Dropdown\" data-nqis=\"Dropdown\">\n                        <div data-nqdisplay=\"small\"><\/div>\n                        <div data-nqdisplay=\"large\"><\/div>\n    \n                        <div class=\"nq-c-Dropdown-toggler nq-c-Heading nq-u-blue\" data-lvl=\"3\" aria-expanded=\"false\">\n                            <span class=\"nq-c-Dropdown-toggler-txt\">Capacidades<\/span>\n                            <span class=\"nq-c-Dropdown-toggler-icon\">\n                                \n                                <span class=\"icon-minus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20.000000pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M936 2697 c-109 -61 -106 -221 5 -277 38 -20 66 -20 1619 -20 1553 0\n1581 0 1619 20 113 57 113 223 0 280 -38 20 -66 20 -1621 20 l-1583 0 -39 -23z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                <span class=\"icon-plus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M2480 4288 c-18 -13 -43 -36 -54 -51 -21 -28 -21 -35 -24 -773 l-2\n-744 -744 -2 c-738 -3 -745 -3 -773 -24 -98 -73 -98 -195 0 -268 28 -21 35\n-21 773 -24 l744 -2 2 -744 c3 -738 3 -745 24 -773 73 -98 195 -98 268 0 21\n28 21 35 24 773 l2 744 744 2 c738 3 745 3 773 24 98 73 98 195 0 268 -28 21\n-35 21 -773 24 l-744 2 -2 744 c-3 738 -3 745 -24 773 -35 48 -82 73 -134 73\n-32 0 -57 -7 -80 -22z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                \n                            <\/span>\n                        <\/div>\n                        <div class=\"nq-c-Dropdown-menu\" hidden>\n                                                            <ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Detecci\u00f3n e identificaci\u00f3n de micropl\u00e1sticos,<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Identificaci\u00f3n y caracterizaci\u00f3n de nanomateriales,<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Novel Food: toda la cadena de valor en nuestros laboratorios, &#8211;<a href=\"https:\/\/www.merieuxnutrisciences.com\/es\/alimentacion\/sectores\/novel-foods\/\" target=\"_blank\" rel=\"noopener\"><em>m\u00e1s informaci\u00f3n sobre novel foods<\/em><\/a><\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Estudios in vitro de permeaci\u00f3n, absorci\u00f3n y eficacia,<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Proyectos customizados (bajo demanda).<\/span><\/li>\n<\/ul>\n    \n                                                                                    <\/div>\n                    <\/div>\n                            \n                                    <div class=\"nq-c-Dropdown\" data-nqis=\"Dropdown\">\n                        <div data-nqdisplay=\"small\"><\/div>\n                        <div data-nqdisplay=\"large\"><\/div>\n    \n                        <div class=\"nq-c-Dropdown-toggler nq-c-Heading nq-u-blue\" data-lvl=\"3\" aria-expanded=\"false\">\n                            <span class=\"nq-c-Dropdown-toggler-txt\">Acreditaciones<\/span>\n                            <span class=\"nq-c-Dropdown-toggler-icon\">\n                                \n                                <span class=\"icon-minus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20.000000pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M936 2697 c-109 -61 -106 -221 5 -277 38 -20 66 -20 1619 -20 1553 0\n1581 0 1619 20 113 57 113 223 0 280 -38 20 -66 20 -1621 20 l-1583 0 -39 -23z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                <span class=\"icon-plus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M2480 4288 c-18 -13 -43 -36 -54 -51 -21 -28 -21 -35 -24 -773 l-2\n-744 -744 -2 c-738 -3 -745 -3 -773 -24 -98 -73 -98 -195 0 -268 28 -21 35\n-21 773 -24 l744 -2 2 -744 c3 -738 3 -745 24 -773 73 -98 195 -98 268 0 21\n28 21 35 24 773 l2 744 744 2 c738 3 745 3 773 24 98 73 98 195 0 268 -28 21\n-35 21 -773 24 l-744 2 -2 744 c-3 738 -3 745 -24 773 -35 48 -82 73 -134 73\n-32 0 -57 -7 -80 -22z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                \n                            <\/span>\n                        <\/div>\n                        <div class=\"nq-c-Dropdown-menu\" hidden>\n                                                            <ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">An\u00e1lisis de micropl\u00e1sticos: primer laboratorio acreditado para alimentos, piensos y aguas,<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">An\u00e1lisis de nanomateriales: acreditaci\u00f3n para TEM, BET, picnometr\u00eda y DLS en m\u00e1s de 15 ensayos,<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Toxicidad aguda en embriones de pez (FET): Test N.\u00ba 236 de la OCDE.<\/span><\/li>\n<\/ul>\n    \n                                                                    <div class=\"wp-block-buttons\">\n                                        <div class=\"wp-block-button is-style-fill\">\n                                            <a class=\"wp-block-button__link\" href=\"https:\/\/drive.google.com\/file\/d\/1b8wptE3rGHPxu5j306rhmLxUkCR_JlsL\/view\" target=\"_blank\" aria-label=\"accordion\" rel=\"noopener\">Consulte todas las acreditaciones<\/a>\n                                        <\/div>\n                                    <\/div>\n                                                                                    <\/div>\n                    <\/div>\n                                    <\/div>\n    \n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Nuestros expertos<\/h2>\n\n\n        <div class=\"wp-block-accordion\">\n            \n                                    <div class=\"nq-c-Dropdown\" data-nqis=\"Dropdown\">\n                        <div data-nqdisplay=\"small\"><\/div>\n                        <div data-nqdisplay=\"large\"><\/div>\n    \n                        <div class=\"nq-c-Dropdown-toggler nq-c-Heading nq-u-blue\" data-lvl=\"3\" aria-expanded=\"false\">\n                            <span class=\"nq-c-Dropdown-toggler-txt\">Federico BENETTI- Director Ejecutivo de ECSIN LAB<\/span>\n                            <span class=\"nq-c-Dropdown-toggler-icon\">\n                                \n                                <span class=\"icon-minus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20.000000pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M936 2697 c-109 -61 -106 -221 5 -277 38 -20 66 -20 1619 -20 1553 0\n1581 0 1619 20 113 57 113 223 0 280 -38 20 -66 20 -1621 20 l-1583 0 -39 -23z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                <span class=\"icon-plus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M2480 4288 c-18 -13 -43 -36 -54 -51 -21 -28 -21 -35 -24 -773 l-2\n-744 -744 -2 c-738 -3 -745 -3 -773 -24 -98 -73 -98 -195 0 -268 28 -21 35\n-21 773 -24 l744 -2 2 -744 c3 -738 3 -745 24 -773 73 -98 195 -98 268 0 21\n28 21 35 24 773 l2 744 744 2 c738 3 745 3 773 24 98 73 98 195 0 268 -28 21\n-35 21 -773 24 l-744 2 -2 744 c-3 738 -3 745 -24 773 -35 48 -82 73 -134 73\n-32 0 -57 -7 -80 -22z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                \n                            <\/span>\n                        <\/div>\n                        <div class=\"nq-c-Dropdown-menu\" hidden>\n                                                            <p><b>Formaci\u00f3n<\/b><span style=\"font-weight: 400;\">: Doctorado en Fisiolog\u00eda Molecular y Biolog\u00eda Estructural por la Universidad de Padua, con amplia experiencia en neurociencia y nanomateriales<\/span><\/p>\n<p><b>Rol<\/b><span style=\"font-weight: 400;\">: Director del laboratorio ECSIN de ECAMRICERT SRL. Experto del grupo nacional sobre nanomateriales del Ministerio de Sanidad italiano. Responsable de proyectos nacionales y europeos como <\/span><b>NANOVALID, NANoREG, NANOREG2, ProSafe, TRANS-INT, GOV4NANO, QNANO, NanoHARMONY<\/b><span style=\"font-weight: 400;\"> y <\/span><b>PlasticsFatE<\/b><span style=\"font-weight: 400;\">. Autor de m\u00e1s de 60 publicaciones cient\u00edficas y t\u00e9cnicas. Participa en la propuesta presentada a la <\/span><b>OCDE<\/b><span style=\"font-weight: 400;\"> para una gu\u00eda sobre un enfoque integrado in vitro del destino intestinal de nanomateriales ingeridos por v\u00eda oral.<\/span><\/p>\n    \n                                                                                    <\/div>\n                    <\/div>\n                            \n                                    <div class=\"nq-c-Dropdown\" data-nqis=\"Dropdown\">\n                        <div data-nqdisplay=\"small\"><\/div>\n                        <div data-nqdisplay=\"large\"><\/div>\n    \n                        <div class=\"nq-c-Dropdown-toggler nq-c-Heading nq-u-blue\" data-lvl=\"3\" aria-expanded=\"false\">\n                            <span class=\"nq-c-Dropdown-toggler-txt\">Elisa GAIO \u2013 Responsable del Laboratorio de Biolog\u00eda<\/span>\n                            <span class=\"nq-c-Dropdown-toggler-icon\">\n                                \n                                <span class=\"icon-minus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20.000000pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M936 2697 c-109 -61 -106 -221 5 -277 38 -20 66 -20 1619 -20 1553 0\n1581 0 1619 20 113 57 113 223 0 280 -38 20 -66 20 -1621 20 l-1583 0 -39 -23z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                <span class=\"icon-plus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M2480 4288 c-18 -13 -43 -36 -54 -51 -21 -28 -21 -35 -24 -773 l-2\n-744 -744 -2 c-738 -3 -745 -3 -773 -24 -98 -73 -98 -195 0 -268 28 -21 35\n-21 773 -24 l744 -2 2 -744 c3 -738 3 -745 24 -773 73 -98 195 -98 268 0 21\n28 21 35 24 773 l2 744 744 2 c738 3 745 3 773 24 98 73 98 195 0 268 -28 21\n-35 21 -773 24 l-744 2 -2 744 c-3 738 -3 745 -24 773 -35 48 -82 73 -134 73\n-32 0 -57 -7 -80 -22z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                \n                            <\/span>\n                        <\/div>\n                        <div class=\"nq-c-Dropdown-menu\" hidden>\n                                                            <p><span style=\"font-weight: 400;\">\u00a0<\/span><b>Formaci\u00f3n<\/b><span style=\"font-weight: 400;\">: Licenciada en Biolog\u00eda M\u00e9dica con Doctorado en Biolog\u00eda Celular y Fisiolog\u00eda por la Universidad de Padua, con amplia experiencia en biolog\u00eda celular.<br \/>\n<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span> <b>Rol<\/b><span style=\"font-weight: 400;\">: Responsable del laboratorio de biolog\u00eda de ECSIN. Experta en el desarrollo y aplicaci\u00f3n de ensayos in vitro. Autora de m\u00e1s de 10 publicaciones cient\u00edficas y t\u00e9cnicas. Directora de estudios conforme a <\/span><b>GLP (Good Laboratory Practice)<\/b><span style=\"font-weight: 400;\">, implicada en el dise\u00f1o y validaci\u00f3n de los planes de estudio.<\/span><\/p>\n    \n                                                                                    <\/div>\n                    <\/div>\n                                    <\/div>\n    \n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Referencias<\/h2>\n\n\n        <div class=\"wp-block-accordion\">\n            \n                                    <div class=\"nq-c-Dropdown\" data-nqis=\"Dropdown\">\n                        <div data-nqdisplay=\"small\"><\/div>\n                        <div data-nqdisplay=\"large\"><\/div>\n    \n                        <div class=\"nq-c-Dropdown-toggler nq-c-Heading nq-u-blue\" data-lvl=\"3\" aria-expanded=\"false\">\n                            <span class=\"nq-c-Dropdown-toggler-txt\">Estudios in vitro de absorci\u00f3n y eficacia<\/span>\n                            <span class=\"nq-c-Dropdown-toggler-icon\">\n                                \n                                <span class=\"icon-minus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20.000000pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M936 2697 c-109 -61 -106 -221 5 -277 38 -20 66 -20 1619 -20 1553 0\n1581 0 1619 20 113 57 113 223 0 280 -38 20 -66 20 -1621 20 l-1583 0 -39 -23z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                <span class=\"icon-plus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M2480 4288 c-18 -13 -43 -36 -54 -51 -21 -28 -21 -35 -24 -773 l-2\n-744 -744 -2 c-738 -3 -745 -3 -773 -24 -98 -73 -98 -195 0 -268 28 -21 35\n-21 773 -24 l744 -2 2 -744 c3 -738 3 -745 24 -773 73 -98 195 -98 268 0 21\n28 21 35 24 773 l2 744 744 2 c738 3 745 3 773 24 98 73 98 195 0 268 -28 21\n-35 21 -773 24 l-744 2 -2 744 c-3 738 -3 745 -24 773 -35 48 -82 73 -134 73\n-32 0 -57 -7 -80 -22z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                \n                            <\/span>\n                        <\/div>\n                        <div class=\"nq-c-Dropdown-menu\" hidden>\n                                                            <p><span style=\"font-weight: 400;\">Los modelos in vitro que imitan diferentes <\/span><b>barreras biol\u00f3gicas<\/b><span style=\"font-weight: 400;\"> pueden utilizarse para llevar a cabo estudios de absorci\u00f3n y evaluar la eficacia de productos, ingredientes o nuevas formulaciones antes de pasar a la siguiente fase de evaluaci\u00f3n (por ejemplo, un ensayo cl\u00ednico).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Los m\u00e9todos in vitro son <\/span><b>menos costosos, m\u00e1s r\u00e1pidos<\/b><span style=\"font-weight: 400;\"> y permiten un mejor control de las variables experimentales que los estudios en humanos o animales, por lo que pueden emplearse f\u00e1cilmente como herramientas de <\/span><b>cribado, clasificaci\u00f3n o categorizaci\u00f3n<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><!-- \/wp:paragraph --> <!-- wp:paragraph --><\/p>\n<p><b>\u00bfPor qu\u00e9 elegir modelos in vitro?<\/b><\/p>\n<ul>\n<li><span style=\"font-weight: 400;\">Reducen los <\/span><b>costes y el tiempo<\/b><b><br \/>\n<\/b><\/li>\n<li><span style=\"font-weight: 400;\">Permiten una<strong> evaluaci\u00f3n m\u00e1s directa<\/strong> del rendimiento del producto, como:<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"> \u25aa Selecci\u00f3n de los<strong> mejores puntos finales<\/strong> para ser investigados en estudios cl\u00ednicos<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"> \u25aa Definici\u00f3n de la <\/span><b>posolog\u00eda<\/b><b><br \/>\n<\/b><span style=\"font-weight: 400;\"> \u25aa Selecci\u00f3n del <\/span><b>prototipo\/formulaci\u00f3n<\/b><span style=\"font-weight: 400;\"> m\u00e1s prometedor(a)<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<\/ul>\n    \n                                                                                    <\/div>\n                    <\/div>\n                            \n                                    <div class=\"nq-c-Dropdown\" data-nqis=\"Dropdown\">\n                        <div data-nqdisplay=\"small\"><\/div>\n                        <div data-nqdisplay=\"large\"><\/div>\n    \n                        <div class=\"nq-c-Dropdown-toggler nq-c-Heading nq-u-blue\" data-lvl=\"3\" aria-expanded=\"false\">\n                            <span class=\"nq-c-Dropdown-toggler-txt\">Biowaivers basados en el sistema BCS \u2013 Clasificaci\u00f3n biofarmac\u00e9utica<\/span>\n                            <span class=\"nq-c-Dropdown-toggler-icon\">\n                                \n                                <span class=\"icon-minus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20.000000pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M936 2697 c-109 -61 -106 -221 5 -277 38 -20 66 -20 1619 -20 1553 0\n1581 0 1619 20 113 57 113 223 0 280 -38 20 -66 20 -1621 20 l-1583 0 -39 -23z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                <span class=\"icon-plus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M2480 4288 c-18 -13 -43 -36 -54 -51 -21 -28 -21 -35 -24 -773 l-2\n-744 -744 -2 c-738 -3 -745 -3 -773 -24 -98 -73 -98 -195 0 -268 28 -21 35\n-21 773 -24 l744 -2 2 -744 c3 -738 3 -745 24 -773 73 -98 195 -98 268 0 21\n28 21 35 24 773 l2 744 744 2 c738 3 745 3 773 24 98 73 98 195 0 268 -28 21\n-35 21 -773 24 l-744 2 -2 744 c-3 738 -3 745 -24 773 -35 48 -82 73 -134 73\n-32 0 -57 -7 -80 -22z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                \n                            <\/span>\n                        <\/div>\n                        <div class=\"nq-c-Dropdown-menu\" hidden>\n                                                            <h2><b>Biowaivers basados en el sistema BCS \u2013 Clasificaci\u00f3n biofarmac\u00e9utica<\/b><\/h2>\n<p><b>BIOWAIVERS BASADOS EN EL SISTEMA<\/b><span style=\"font-weight: 400;\"> \u2013 Gu\u00eda sobre clasificaci\u00f3n biofarmac\u00e9utica EMA\/ICH M9, FDA M9 Biopharmaceutics Classification<\/span><\/p>\n<h3><b>Resumen<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Este documento ofrece orientaci\u00f3n sobre la aplicaci\u00f3n de <\/span><a href=\"https:\/\/database.ich.org\/sites\/default\/files\/M9_Guideline_Step4_2019_1116.pdf\" target=\"_blank\" rel=\"noopener\"><b>biowaivers basados en el Sistema de Clasificaci\u00f3n Biofarmac\u00e9utica (BCS) (<\/b><b><i>Biopharmaceutics Classification System (BCS)-based biowaivers<\/i><\/b><b>)<\/b><span style=\"font-weight: 400;\">.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/a><span style=\"font-weight: 400;\"> Se centra en los m\u00e9todos para apoyar la clasificaci\u00f3n de principios activos y justificar la bioequivalencia <\/span><b>sin necesidad de estudios in vivo<\/b><span style=\"font-weight: 400;\">, garantizando seguridad y eficacia consistentes.<\/span><\/p>\n<h3><b>Alcance del documento<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Aplicable a formas farmac\u00e9uticas orales de <\/span><b>liberaci\u00f3n inmediata<\/b><span style=\"font-weight: 400;\">, s\u00f3lidas o en suspensi\u00f3n.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"> Relevante para <\/span><b>cambios post-autorizaci\u00f3n<\/b><span style=\"font-weight: 400;\">, solicitudes de gen\u00e9ricos y productos en desarrollo cl\u00ednico.<\/span><\/p>\n<h2><b>M\u00e9todo de ensayo de permeabilidad en Caco-2<\/b><\/h2>\n<h3><b>Alcance y aplicaci\u00f3n<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Permite estimar la <\/span><b>absorci\u00f3n intestinal de f\u00e1rmacos<\/b><span style=\"font-weight: 400;\"> utilizando monocapas de c\u00e9lulas epiteliales Caco-2 cultivadas.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"> Validado para el transporte pasivo de medicamentos, especialmente \u00fatil para clasificar f\u00e1rmacos de <\/span><b>alta permeabilidad<\/b><span style=\"font-weight: 400;\"> dentro del sistema BCS.<\/span><\/p>\n<h3><b>Validaci\u00f3n y fiabilidad<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">La validaci\u00f3n debe incluir una <\/span><b>relaci\u00f3n ordenada entre permeabilidad y grado de absorci\u00f3n humana<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Requiere m\u00faltiples replicados y f\u00e1rmacos modelo para asegurar fiabilidad y consistencia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">El m\u00e9todo debe demostrar independencia respecto a mecanismos de transporte activo para una clasificaci\u00f3n de permeabilidad precisa<\/span><\/li>\n<\/ul>\n    \n                                                                                    <\/div>\n                    <\/div>\n                            \n                                    <div class=\"nq-c-Dropdown\" data-nqis=\"Dropdown\">\n                        <div data-nqdisplay=\"small\"><\/div>\n                        <div data-nqdisplay=\"large\"><\/div>\n    \n                        <div class=\"nq-c-Dropdown-toggler nq-c-Heading nq-u-blue\" data-lvl=\"3\" aria-expanded=\"false\">\n                            <span class=\"nq-c-Dropdown-toggler-txt\">Ensayo de liberaci\u00f3n in vitro (IVRT) \u2013 Calidad y equivalencia de productos t\u00f3picos farmac\u00e9uticos y sanitarios<\/span>\n                            <span class=\"nq-c-Dropdown-toggler-icon\">\n                                \n                                <span class=\"icon-minus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20.000000pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M936 2697 c-109 -61 -106 -221 5 -277 38 -20 66 -20 1619 -20 1553 0\n1581 0 1619 20 113 57 113 223 0 280 -38 20 -66 20 -1621 20 l-1583 0 -39 -23z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                <span class=\"icon-plus-accordion\"><?xml version=\"1.0\" standalone=\"no\"?>\n<!DOCTYPE svg PUBLIC \"-\/\/W3C\/\/DTD SVG 20010904\/\/EN\"\n \"http:\/\/www.w3.org\/TR\/2001\/REC-SVG-20010904\/DTD\/svg10.dtd\">\n<svg version=\"1.0\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n width=\"20pt\" height=\"20pt\" viewBox=\"0 0 512.000000 512.000000\"\n preserveAspectRatio=\"xMidYMid meet\">\n\n<g transform=\"translate(0.000000,512.000000) scale(0.100000,-0.100000)\"\nfill=\"#000000\" stroke=\"none\">\n<path d=\"M2480 4288 c-18 -13 -43 -36 -54 -51 -21 -28 -21 -35 -24 -773 l-2\n-744 -744 -2 c-738 -3 -745 -3 -773 -24 -98 -73 -98 -195 0 -268 28 -21 35\n-21 773 -24 l744 -2 2 -744 c3 -738 3 -745 24 -773 73 -98 195 -98 268 0 21\n28 21 35 24 773 l2 744 744 2 c738 3 745 3 773 24 98 73 98 195 0 268 -28 21\n-35 21 -773 24 l-744 2 -2 744 c-3 738 -3 745 -24 773 -35 48 -82 73 -134 73\n-32 0 -57 -7 -80 -22z\"\/>\n<\/g>\n<\/svg>\n<\/span>\n                                \n                            <\/span>\n                        <\/div>\n                        <div class=\"nq-c-Dropdown-menu\" hidden>\n                                                            <h3><b>SUPAC-SS Qu\u00edmica, fabricaci\u00f3n y control: ensayos de liberaci\u00f3n in vitro y bioequivalencia in vivo<\/b><\/h3>\n<h3><b>Resumen<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">La gu\u00eda ofrece recomendaciones para los patrocinadores farmac\u00e9uticos ante <\/span><b>modificaciones en componentes, composici\u00f3n, procesos de fabricaci\u00f3n, escalado y cambio de planta<\/b><span style=\"font-weight: 400;\"> en formas farmac\u00e9uticas semis\u00f3lidas no est\u00e9riles.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">El objetivo es asegurar la <\/span><b>calidad continua del producto<\/b><span style=\"font-weight: 400;\"> y el mantenimiento de sus caracter\u00edsticas de desempe\u00f1o para formulaciones t\u00f3picas semis\u00f3lidas como <\/span><b>cremas, geles, lociones y pomadas<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><b>Alcance y aplicaci\u00f3n<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Aplica a solicitudes de <strong>nuevos medicamentos (NDAs)<\/strong>, <strong>solicitudes abreviadas (ANDAs)<\/strong> y <strong>solicitudes de antibi\u00f3ticos (AADAs)<\/strong> para formas semis\u00f3lidas no est\u00e9riles.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"> Define los niveles de cambio, pruebas recomendadas de qu\u00edmica, fabricaci\u00f3n y control (<\/span><b>CMC<\/b><span style=\"font-weight: 400;\">), ensayos de liberaci\u00f3n in vitro y pruebas de bioequivalencia in vivo necesarias para respaldar dichos cambios.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tambi\u00e9n especifica la informaci\u00f3n exigida por el <\/span><b>Centro de Evaluaci\u00f3n e Investigaci\u00f3n de Medicamentos (CDER)<\/b><span style=\"font-weight: 400;\"> para garantizar la calidad del producto.<\/span><\/p>\n<h3><b>Ensayos in vitro<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">El ensayo de liberaci\u00f3n in vitro compara las <\/span><b>velocidades de liberaci\u00f3n<\/b><span style=\"font-weight: 400;\"> de distintas series del producto utilizando celdas de difusi\u00f3n.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">El ensayo se realiza en dos etapas<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Se calculan <\/span><b>intervalos de confianza<\/b><span style=\"font-weight: 400;\"> para verificar que las tasas de liberaci\u00f3n est\u00e9n dentro de los l\u00edmites aceptables<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Este m\u00e9todo asegura la <\/span><b>consistencia de la liberaci\u00f3n del principio activo<\/b><span style=\"font-weight: 400;\"> tras cambios de fabricaci\u00f3n<\/span><\/li>\n<\/ul>\n<h2><b>Productos farmac\u00e9uticos t\u00f3picos presentados en ANDAs: Estudios IVRT de la FDA<\/b><\/h2>\n<h3><b>Resumen<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">El IVRT est\u00e1 dise\u00f1ado para <\/span><a href=\"https:\/\/www.fda.gov\/media\/162476\/download\" target=\"_blank\" rel=\"noopener\"><b>evaluar la velocidad de liberaci\u00f3n del principio activo<\/b><\/a><span style=\"font-weight: 400;\"> en productos t\u00f3picos.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Es clave para demostrar <\/span><b>bioequivalencia<\/b><span style=\"font-weight: 400;\"> entre medicamentos gen\u00e9ricos y productos de referencia<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Act\u00faa como herramienta predictiva para evaluar el desempe\u00f1o del producto<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Garantiza la consistencia en fabricaci\u00f3n y respalda la presentaci\u00f3n de documentaci\u00f3n regulatoria<\/span><\/li>\n<\/ul>\n<h3><b>Alcance del documento<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Uso en presentaciones regulatorias para ANDAs, como prueba de <\/span><b>bioequivalencia (BE)<\/b><span style=\"font-weight: 400;\"> de productos t\u00f3picos<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplicable a diversas formulaciones semis\u00f3lidas y l\u00edquidas: <\/span><b>cremas, pomadas, geles y lociones<\/b><span style=\"font-weight: 400;\">, administradas sobre la piel o mucosas<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Esencial para productos donde los estudios in vivo no son viables o son poco pr\u00e1cticos<\/span><\/li>\n<\/ul>\n<h3><b>Validaci\u00f3n del m\u00e9todo<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">La validaci\u00f3n asegura la fiabilidad mediante:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Calificaci\u00f3n del equipo y de las membranas<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Selecci\u00f3n de soluciones receptoras adecuadas<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muestreo preciso y condiciones ambientales controladas<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confirmaci\u00f3n de liberaci\u00f3n lineal del f\u00e1rmaco <strong>(r\u00b2 \u2265 0.97)<\/strong><\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Demostraci\u00f3n de precisi\u00f3n (<\/span><b>CV \u2264 15\u202f%<\/b><span style=\"font-weight: 400;\">) y reproducibilidad<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Se verifica la capacidad de discriminaci\u00f3n para diferenciar formulaciones con distintas velocidades de liberaci\u00f3n, lo que respalda la <\/span><b>aceptaci\u00f3n regulatoria y la bioequivalencia<\/b><span style=\"font-weight: 400;\"> de los productos t\u00f3picos.<\/span><\/p>\n    \n                                                                                    <\/div>\n                    <\/div>\n                                    <\/div>\n    \n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Nuestros servicios<\/h2>\n\n\n\n<div style=\"height:9px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-absorption-and-efficacy-studies-by-in-vitro-models\"><strong>Estudios de Absorci\u00f3n y Eficacia mediante Modelos <em>In Vitro<\/em><\/strong><\/h3>\n\n\n\n<p>Los ensayos y modelos <strong><em>in vitro<\/em><\/strong> respaldan todo el proceso de fabricaci\u00f3n farmac\u00e9utica, desde la concepci\u00f3n inicial hasta la comercializaci\u00f3n del producto. Gracias a las distintas aplicaciones<em> in vitro<\/em>, es posible <strong>simular los efectos de los f\u00e1rmacos<\/strong> a trav\u00e9s de modelos biol\u00f3gicos y estudios de absorci\u00f3n, realizando m\u00faltiples pruebas de cribado como:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Identificaci\u00f3n del <strong>mejor principio activo<\/strong> para un objetivo concreto<\/li>\n\n\n\n<li>Optimizaci\u00f3n de la formulaci\u00f3n para mejorar su <strong>actividad biol\u00f3gica<\/strong> y propiedades<\/li>\n\n\n\n<li>Evaluaci\u00f3n preliminar de la <strong>bioaccesibilidad<\/strong> y <strong>biodisponibilidad<\/strong><\/li>\n\n\n\n<li>Evaluaci\u00f3n de la <strong>eficacia<\/strong>, con el fin de valorar previamente el producto, ingrediente o formulaci\u00f3n antes de avanzar a la siguiente etapa (por ejemplo, ensayo cl\u00ednico)<\/li>\n<\/ol>\n\n\n\n<ol class=\"wp-block-list\">\n<li><\/li>\n<\/ol>\n\n\n\n<p>Nuestros expertos pueden desarrollar modelos <em>in vitro<\/em> <strong>diversos y personalizados<\/strong> para distintas aplicaciones, capaces de reproducir los efectos de los f\u00e1rmacos mediante simulaci\u00f3n biol\u00f3gica y estudios de absorci\u00f3n. Esto permite realizar pruebas de cribado previas para <strong>evaluar de forma preliminar<\/strong> un producto, ingrediente o formulaci\u00f3n antes de pasar a la siguiente fase de evaluaci\u00f3n (como ensayos cl\u00ednicos).<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a0e3c9fae0aa&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6a0e3c9fae0aa\" class=\"aligncenter size-full is-resized wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"2880\" height=\"1620\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/invitro-model-digestion_pagina-studi-assorbimento_Tavola-disegno-1-scaled.jpg\" alt=\"\" class=\"wp-image-177826\" style=\"width:800px\" srcset=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/invitro-model-digestion_pagina-studi-assorbimento_Tavola-disegno-1-scaled.jpg 2880w, https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/invitro-model-digestion_pagina-studi-assorbimento_Tavola-disegno-1-300x169.jpg 300w, https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/invitro-model-digestion_pagina-studi-assorbimento_Tavola-disegno-1-1024x576.jpg 1024w, https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/invitro-model-digestion_pagina-studi-assorbimento_Tavola-disegno-1-768x432.jpg 768w, https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/invitro-model-digestion_pagina-studi-assorbimento_Tavola-disegno-1-1536x864.jpg 1536w, https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/invitro-model-digestion_pagina-studi-assorbimento_Tavola-disegno-1-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 2880px) 100vw, 2880px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Agrandar\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-absorption-and-efficacy-studies-by-in-vitro-models\"><strong>Modelos biol\u00f3gicos<\/strong><\/h3>\n\n\n\n<div style=\"height:7px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Los <strong>modelos biol\u00f3gicos<\/strong> est\u00e1n compuestos por fluidos biol\u00f3gicos que representan el proceso digestivo, suero plasm\u00e1tico, tejido cerebral, coraz\u00f3n y sangre, pr\u00f3stata y muchos otros.<br>Estos modelos son <strong>implementables y adaptables<\/strong> en funci\u00f3n del tipo de fluido o del estudio que se desee realizar, y de acuerdo con las necesidades del cliente.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Estudio con Protocolo de Cribado<\/strong><\/h4>\n\n\n\n<p><strong>Ensayo de disoluci\u00f3n<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ensayo de disoluci\u00f3n est\u00e1ndar conforme a EP\/USP<br><\/li>\n\n\n\n<li>Ensayo de disoluci\u00f3n de liberaci\u00f3n retardada\/progresiva conforme a EP\/USP<br><\/li>\n<\/ul>\n\n\n\n<p><strong>An\u00e1lisis de absorci\u00f3n tipo \u201cShot-Gun\u201d<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Evaluaci\u00f3n preliminar de la biodisponibilidad \u2013 nivel sist\u00e9mico (<em>uso interno<\/em>): estudio de absorci\u00f3n gastrointestinal mediante modelo in vitro de 2 etapas<br><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Estudio con Protocolo Completo<\/strong><\/h4>\n\n\n\n<p><strong>Estudio completo de absorci\u00f3n<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Evaluaci\u00f3n de la biodisponibilidad \u2013 nivel sist\u00e9mico (<em>uso regulatorio y\/o divulgaci\u00f3n cient\u00edfica<\/em>): estudio de absorci\u00f3n gastrointestinal mediante modelo in vitro de 2 etapas<br><\/li>\n<\/ul>\n\n\n\n<p><strong>Estudio completo de absorci\u00f3n con modelo personalizado avanzado<\/strong>: Evaluaci\u00f3n de la biodisponibilidad \u2013 nivel sist\u00e9mico (<em>uso regulatorio y\/o divulgaci\u00f3n cient\u00edfica<\/em>): estudio de absorci\u00f3n gastrointestinal mediante modelo <em>in vitro<\/em> de 2 etapas.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Enfoque de Biowaiver Basado en el Sistema BCS<\/strong><\/h2>\n\n\n\n<p>Dos medicamentos que contienen la misma sustancia activa se consideran <strong>bioequivalentes<\/strong> si su <strong>biodisponibilidad<\/strong> (velocidad y grado de absorci\u00f3n) tras la administraci\u00f3n de la misma dosis molar est\u00e1 dentro de los l\u00edmites aceptables predefinidos.<\/p>\n\n\n\n<p>El enfoque <strong>BCS (Biopharmaceutics Classification System)<\/strong> tiene como objetivo <strong>reducir la necesidad de estudios <em>in vivo<\/em><\/strong> <strong>para demostrar bioequivalencia.<\/strong><\/p>\n\n\n\n<p>El BCS clasifica los principios activos en funci\u00f3n de su <strong>solubilidad acuosa<\/strong> y <strong>permeabilidad intestinal<\/strong> en una de las cuatro clases:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Clase I<\/strong>: alta solubilidad, alta permeabilidad \u2013 BCS APLICABLE<br><\/li>\n\n\n\n<li><strong>Clase II<\/strong>: baja solubilidad, alta permeabilidad \u2013 BCS NO APLICABLE<br><\/li>\n\n\n\n<li><strong>Clase III<\/strong>: alta solubilidad, baja permeabilidad \u2013 BCS APLICABLE<br><\/li>\n\n\n\n<li><strong>Clase IV<\/strong>: baja solubilidad, baja permeabilidad \u2013 BCS NO APLICABLE<\/li>\n<\/ul>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-drug-topical-products\"><strong><strong>Productos T\u00f3picos<\/strong><\/strong><\/h2>\n\n\n\n<div style=\"height:11px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-in-vitro-release-testing-ivrt-for-topical-formulations\"><strong><strong>Ensayos de Liberaci\u00f3n <em>In Vitro<\/em> (IVRT) para Formulaciones T\u00f3picas<\/strong><\/strong>:<\/h3>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>El ensayo <strong><strong>de Liberaci\u00f3n <em>In Vitro<\/em><\/strong><\/strong> (<strong>IVRT<\/strong>) es un m\u00e9todo cr\u00edtico para evaluar el rendimiento de formas farmac\u00e9uticas t\u00f3picas, normalmente utilizando un sistema de celda de difusi\u00f3n de c\u00e1mara abierta, como la celda de Franz.<br>Puede utilizarse como herramienta de I+D para <strong>optimizar formulaciones<\/strong> y como herramienta de <strong>control de calidad<\/strong> para evaluar la consistencia de fabricaci\u00f3n en el tiempo.<\/p>\n\n\n\n<p>Las <strong>condiciones experimentales<\/strong> \u2013tipo de membrana, medio receptor e intervalos de muestreo\u2013 se optimizan seg\u00fan las propiedades fisicoqu\u00edmicas del principio activo (API):<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>El <strong>producto<\/strong> se aplica sobre una membrana sint\u00e9tica en la <strong>c\u00e1mara donadora.<\/strong><br><\/li>\n\n\n\n<li>El<strong> l\u00edquido receptor <\/strong>se coloca en la c\u00e1mara receptora bajo la membrana.<br><\/li>\n\n\n\n<li>La <strong>difusi\u00f3n del API<\/strong> se monitoriza mediante muestreo secuencial del fluido receptor.<br><\/li>\n\n\n\n<li>La <strong>tasa de liberaci\u00f3n (flujo)<\/strong> se calcula graficando la liberaci\u00f3n acumulada media frente a la ra\u00edz cuadrada del tiempo.<br><\/li>\n\n\n\n<li>Esta tasa de liberaci\u00f3n espec\u00edfica por formulaci\u00f3n sirve para control de calidad, desarrollo de producto y validaci\u00f3n de escalado o cambios post-autorizaci\u00f3n.<br><\/li>\n<\/ul>\n\n\n\n<p>Se comparan lotes antes y despu\u00e9s del cambio, calculando un <strong>intervalo de confianza del 90\u202f%<\/strong>, que debe situarse entre <strong>75\u202f% y 133,33\u202f%<\/strong> para demostrar consistencia.<\/p>\n\n\n\n<hr>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-our-scientific-writing-on-absorption-and-efficacy-studies-by-in-vitro-models\"><strong><strong><strong>Publicaciones Cient\u00edficas sobre Estudios de Absorci\u00f3n y Eficacia mediante Modelos <em>In Vitro<\/em><\/strong><\/strong><\/strong>:<\/h2>\n\n\n\n<p><em>In vitro<\/em> studies to assess the capacity of the nanocomplexes to control the release of the associated insulin \u2013 \u201c<a href=\"https:\/\/scholar.google.it\/citations?view_op=view_citation&amp;hl=it&amp;user=rpdS5v0AAAAJ&amp;sortby=pubdate&amp;citation_for_view=rpdS5v0AAAAJ:tKAzc9rXhukC\" target=\"_blank\" rel=\"noopener\"><em>Bioinspired orthogonal-shaped protein\u2013biometal nanocrystals enable oral protein absorption<\/em><\/a><em>\u201d<\/em> &#8211; M Dur\u00e1n-Lobato <em>et. Al<\/em>. Journal of Controlled Release 377, 17-36<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>In-vitro<\/em> effect of a novel combination of active substances \u2013 <em>\u201c<\/em><a href=\"https:\/\/scholar.google.it\/citations?view_op=view_citation&amp;hl=it&amp;user=rpdS5v0AAAAJ&amp;sortby=pubdate&amp;citation_for_view=rpdS5v0AAAAJ:PR6Y55bgFSsC\" target=\"_blank\" rel=\"noopener\"><em>Effects of a novel combination of magnesium, tryptophan, resveratrol, and saffron on oxidative stress, prostaglandin F2\u03b1, and intracellular Ca<\/em><em><sup>2+<\/sup><\/em><em> levels in an in-vitro<\/em><em> model of myometrium<\/em><\/a><em>\u201d<\/em> &#8211; S Battaglia, M Cozzi, FR Ranieri, E Gaio, F Benetti, V Curti. Minerva Biotechnology &amp; Biomolecular Research 35 (4)<\/li>\n\n\n\n<li><em>In vitro<\/em> model to evaluate the digestive process and fermentation using simulated digestive fluids and Caco-2 cells \u2013<strong> <\/strong><strong><em>\u201c<\/em><\/strong><a href=\"https:\/\/doi.org\/10.4081\/jbr.2023.11154\" target=\"_blank\" rel=\"noopener\"><em>Evaluation of Short Chain Fatty Acids (SCFAs) intestinal absorption, following digestion and fermentation of a novel medical device containing partially-hydrolyzed Guar gum plus simethicone<\/em><\/a><em>\u201d<\/em> &#8211; Benetti, F., Micheletto, M., Tedesco, E., Gaio, E., &amp; Ciprandi, G. (2023). <em>Journal of Biological Research &#8211; Bollettino Della Societ\u00e0 Italiana Di Biologia Sperimentale<\/em>, <em>96 <\/em>(1)<\/li>\n\n\n\n<li><em>In vitro <\/em>study for urothelial inflammation treatment \u2013 \u201c<a href=\"https:\/\/doi.org\/10.3390\/cells12040616\" target=\"_blank\" rel=\"noopener\"><em>Micronized Palmitoylethanolamide, Hempseed Oil, and Maritime Pine Bark Dry Extract (Pelvipea<\/em><em><sup>\u00ae<\/sup><\/em><em>) for Pelvic Pain: An In Vitro Study for Urothelial Inflammation Treatment<\/em><\/a><em>\u201d<\/em> &#8211; Tafuri, A.; Panunzio, A.; De Mitri, R.; Benetti, F.; Gaio, E.; Pagliarulo, V. &#8211; <em>Cells<\/em> 2023, <em>12<\/em>, 616<\/li>\n\n\n\n<li><em>In vitro<\/em> behaviour of chitosan coated liposomes &#8211; <a href=\"https:\/\/www.longdom.org\/open-access\/analysis-of-operating-conditions-influencing-the-morphology-and-in-vitro-behaviour-of-chitosan-coated-liposomes-2157-7439.1000211.pdf\" target=\"_blank\" rel=\"noopener\"><strong><em>\u201cAnalysis of operating conditions influencing the morphology and in vitro behaviour of chitosan coated liposomes\u201d<\/em><\/strong><\/a> &#8211; J Nanomed Nanotechnol 5: 211<\/li>\n\n\n\n<li><em>In vitro<\/em> efficacy testing to understand the mechanism of action \u2013 \u201c<strong><em>Capryloyl glycine and soy isoflavonoids in hypertrichosis: an experimental and placebo-controlled clinical study<\/em><\/strong>\u201d, DOI: 10.1111\/jocd.14096 -J Cosmet Dermatol. 2021;20(Suppl. 1):18\u201322<\/li>\n\n\n\n<li>Digestive model through an integrated <em>in vitro<\/em> approach \u2013 <strong><em>\u201cComparative evaluation of intestinal absorption and functional value of iron dietary supplements and drug with different delivery systems\u201d<\/em><\/strong>, Molecules 2020, 25(24), 5989<\/li>\n\n\n\n<li><em>In vitro<\/em> models that compare different commercial dietary supplements containing stabilized OSA to ascertain their bioaccessibility, bioavailability, and safety in a model of human intestinal epithelium \u2013 <a href=\"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/epdf\/10.1096\/fj.202000060RR\" target=\"_blank\" rel=\"noopener\"><em>\u201c<\/em><strong><em>In vitro evaluation of different organic matrices used to modulate silicon bioavailability<\/em><\/strong><em>\u201d<\/em><\/a>, The FASEB Journal. 2020;34:12229\u201312238<\/li>\n\n\n\n<li>Iron bioaccessibility, bioavailability, and intestinal absorption mechanisms \u2013 <a href=\"https:\/\/doi.org\/10.3390\/molecules25245989\" target=\"_blank\" rel=\"noopener\"><strong>\u201c<\/strong><strong><em>Comparative Evaluation of Intestinal Absorption and Functional Value of Iron Dietary Supplements and Drug with Different Delivery Systems\u201d<\/em><\/strong><\/a>, <em>Molecules<\/em>, <em>25<\/em>, 5989<\/li>\n\n\n\n<li><em>In vitro<\/em> toxicity assessment of oral nanocarriers \u2013 <a href=\"https:\/\/doi.org\/10.1016\/j.addr.2016.08.007\" target=\"_blank\" rel=\"noopener\"><strong>\u201c<\/strong><strong><em>In vitro toxicity assessment of oral nanocarriers\u201d<\/em><\/strong><\/a>, Advanced Drug Delivery Reviews, Volume 106, Part B, 2016, Pages 381-401, ISSN 0169-409X<\/li>\n<\/ul>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-i-modelli-in-vitro\"><strong>Modelos <em>In Vitro<\/em><\/strong> disponibles:<\/h2>\n\n\n\n<p><strong>M\u00e9rieux NutriSciences<\/strong> puede apoyar todos tus proyectos mediante una <strong>amplia gama de modelos <em>in vitro<\/em><\/strong>, que pueden ser implementados y adaptados en funci\u00f3n del tipo de fluido o estudio, as\u00ed como seg\u00fan las necesidades del cliente.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Modelo in vitro oral: absorci\u00f3n o irritaci\u00f3n oral y sublingual<\/li>\n\n\n\n<li>Modelo in vitro nasal: absorci\u00f3n o irritaci\u00f3n nasal<\/li>\n\n\n\n<li>Modelo digestivo in vitro: bioaccesibilidad<\/li>\n\n\n\n<li>Modelo de absorci\u00f3n intestinal in vitro: biodisponibilidad<\/li>\n\n\n\n<li>Modelo d\u00e9rmico in vitro: estudios de absorci\u00f3n y eficacia<\/li>\n\n\n\n<li>Modelo gastrointestinal in vitro<\/li>\n\n\n\n<li>Modelo hep\u00e1tico in vitro<\/li>\n\n\n\n<li>Modelo cerebral in vitro<\/li>\n\n\n\n<li>Modelo prost\u00e1tico in vitro<\/li>\n\n\n\n<li>Modelos in vitro de coraz\u00f3n y vasos sangu\u00edneos<\/li>\n\n\n\n<li>Modelos in vitro de monocitos y macr\u00f3fagos<\/li>\n<\/ul>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns has-theme-palette-8-background-color has-background is-layout-flex wp-container-core-columns-is-layout-62db62f3 wp-block-columns-is-layout-flex\" style=\"padding-top:0;padding-bottom:0\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0;padding-bottom:0\">\n<h3 class=\"wp-block-heading has-text-align-center\">Descargue nuestro cat\u00e1logo de servicios para productos farmac\u00e9uticos<\/h3>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><a href=\"https:\/\/drive.google.com\/file\/d\/1EmVaOs6i-Og_YAGHF0e21bYQVu0Tt_2G\/view\" target=\"_blank\" rel=\" noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/Pharma-Service-Catalogue-EN.jpg\" alt=\"\" class=\"wp-image-179204\" style=\"width:auto;height:300px\"\/><\/a><\/figure>\n<\/div>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/drive.google.com\/file\/d\/1EmVaOs6i-Og_YAGHF0e21bYQVu0Tt_2G\/view\" target=\"_blank\" rel=\"noopener\"><strong>DESCARGAR<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n<\/div>\n\n\n<div class=\"page-cards-block-wrapper fullwidth-block\">   \n    <div class=\"page-cards-title-container\"> \n        <h2>Servicios relacionados<\/h2>    \n    <\/div>\n    <div class=\"full-width-row-page-cards-wrapper\">\n        <div class=\"page-cards-container\">\n                                            <a href=\"https:\/\/www.merieuxnutrisciences.com\/es\/servicios-farmaceuticos\/ensayos-de-impurezas\/\" class=\"card\">\n                                            <img decoding=\"async\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2024\/08\/Analisi-delle-impurezze-blu.png\" alt=\"Ensayos de Impurezas\" class=\"card-icon\"\/>\n                                        <div class=\"card-content\">\n                        <span>Ensayos de Impurezas<\/span>\n                    <\/div>\n                <\/a>\n                                            <a href=\"https:\/\/www.merieuxnutrisciences.com\/es\/servicios-farmaceuticos\/envases-farmaceuticos\/\" class=\"card\">\n                                            <img decoding=\"async\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2025\/07\/icona-packaging-11.png\" alt=\"Envases Farmac\u00e9uticos\" class=\"card-icon\"\/>\n                                        <div class=\"card-content\">\n                        <span>Envases Farmac\u00e9uticos<\/span>\n                    <\/div>\n                <\/a>\n                                            <a href=\"https:\/\/www.merieuxnutrisciences.com\/es\/servicios-farmaceuticos\/estudios-de-estabilidad-almacenamiento\/\" class=\"card\">\n                                            <img decoding=\"async\" src=\"https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2024\/08\/Test-di-stabilita-e-stoccaggio-campioni-blu.png\" alt=\"Estudios de Estabilidad y Almacenamiento\" class=\"card-icon\"\/>\n                                        <div class=\"card-content\">\n                        <span>Estudios de Estabilidad y Almacenamiento<\/span>\n                    <\/div>\n                <\/a>\n                                <\/div>\n    <\/div>\n<\/div>    \n   \n\n<style>\n.fullwidth-block {\n    max-width: none !important;\n    width: 100vw !important;\n    position: relative;\n    padding:0px;\n    \/* left: 50%;\n    right: 50%;\n    margin-left: -50vw;\n    margin-right: -50vw; *\/\n}\n\n.page-cards-title-container{\n    max-width: 1290px;\n    margin: 100px auto 150px 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auto;\n    margin-bottom: 10px;\n}\n.card-content{\n    display:flex;\n    justify-content: center;\n}\n\n.card-content span{\n    color:var(--global-palette3);\n    text-align: center;\n    text-transform: uppercase;\n    margin: 5px 0;\n    line-height: 1.2em;\n    font-size: 16px;\n    font-weight:bold;\n}\n\n.card:hover {\n    animation: all ease-in-out 0.3s;\n    transform: scale(.95) translate(0px, -100px);\n    box-shadow: 0 4px 8px rgba(0,0,0,0.2);\n}\n\n@media (max-width: 767px) {\n    .page-cards-container {\n        flex-direction: column;\n        align-items: center;\n    }\n    .page-cards-title-container{\n        text-align: center;\n    }\n    \n}\n\n@media (min-width: 768px) and (max-width: 1023px) {\n    .page-cards-container {\n        flex-wrap: wrap;\n        justify-content: space-around;\n    }\n    .page-cards-title-container{\n        text-align: center;\n    }\n\n}\n\n<\/style>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ubicado en Italia, ECSIN LAB \u2013 parte del grupo M\u00e9rieux NutriSciences \u2013 es un laboratorio de innovaci\u00f3n que combina el enfoque hacia la eficacia de las soluciones propuestas con la participaci\u00f3n en proyectos cient\u00edficos estrat\u00e9gicos internacionales innovadores. Estudios de Absorci\u00f3n: Nuestro Laboratorio Nuestros expertos Referencias Nuestros servicios Estudios de Absorci\u00f3n y Eficacia mediante Modelos In&#8230;<\/p>\n","protected":false},"author":83,"featured_media":113132,"parent":191630,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"service-page-pharma-blue.php","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"folder":[],"class_list":["post-194621","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"taxonomy_info":[],"featured_image_src_large":["https:\/\/www.merieuxnutrisciences.com\/wp-content\/uploads\/2024\/09\/shutterstock_744413632_Extractables-and-leachables.jpg",1024,576,false],"author_info":{"display_name":"Eric Miranda","author_link":"https:\/\/www.merieuxnutrisciences.com\/es\/author\/ericmiranda\/"},"comment_info":0,"_links":{"self":[{"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/pages\/194621","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/users\/83"}],"replies":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/comments?post=194621"}],"version-history":[{"count":20,"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/pages\/194621\/revisions"}],"predecessor-version":[{"id":246793,"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/pages\/194621\/revisions\/246793"}],"up":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/pages\/191630"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/media\/113132"}],"wp:attachment":[{"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/media?parent=194621"}],"wp:term":[{"taxonomy":"folder","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com\/es\/wp-json\/wp\/v2\/folder?post=194621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}